Fabry hastalarında vestibüler fonksiyonun değerlendirilmesi
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Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Fabry hastalığı, ikinci en sık görülen lizozomal depo bozukluğudur.
Literatürde bu hastalıkla ilgili çok sayıda işitme fonksiyonlarının değerlendirildiği çalışma
bulunmasına rağmen denge fonksiyonları ile ilgili az sayıda yayın bulunmaktadır. Bu
çalışmada, Fabry hastalarında vestibüler fonksiyonun değerlendirilmesi amaçlanmıştır.
Yöntem: Çalışmaya 13 Fabry hastası ve yaş-cinsiyet uyumlu 14 sağlıklı kontrol
grubu dahil edildi. Her iki gruba otoskopik muayene ve vestibüler sistem muayenesi ile
birlikte Videonistagmografi(VNG), Video Head Impulse Test(v-HIT), Postürografi testleri
yapıldı.
Bulgular: Çalışmaya dahil edilen Fabry hastalarının 7’i (%53.8) kadın ve 6’sı
(%46.1) erkekti. Kontrol grubunun ise 5’i (%35.7) kadın, 9’u (%64.2) erkekti. Postürografi
testinde bütün skorlarda kontrol grubunun skorları hastaların skorlarından daha yüksek
olmasına rağmen istatistiksel olarak anlamlı farklılık bulunmadı (p>0.05). Kalorik testte 13
kişilik hasta grubundan 7 kişide (%53) vestibüler hipofonksiyon tespit edilirken, kontrol
grubunda kanal parezesi saptanmadı. Hasta ve kontrol grubu arasındaki bu fark istatistiksel
olarak anlamlı idi (p<0.05). Hasta ve kontrol grupları arasında anterior, lateral ve posterior
kanallar kazanç oranları açısından istatistiksel olarak anlamlı farklılık bulunmadı
(p=0.5666).
Sonuç: Fabry hastalarında vestibüler tutulum olabileceği, bu nedenle hastaların
tedavi ve izlem sürecinde denge sistemlerinin de göz önünde bulundurulması gerektiğini
düşünüyoruz.
Objective: Fabry disease is the second most common lysosomal storage disorder. Although there are many studies evaluating hearing functions related to this disease in the literature, there are few publications on balance functions. In this study, it was aimed to evaluate vestibular function in Fabry patients. Methods: Thirteen Fabry patients and 14 age-sex matched healthy controls were included in the study. Videonystagmography (VNG), Video Head Impulse Test (v-HIT), Posturography tests were performed together with otoscopic examination and vestibular system examination in both groups. Results: Of the Fabry patients included in the study, 7 (53.8%) were female and 6 (46.1%) were male. In the control group, 5 (35.7%) were female and 9 (64.2%) were male. Although the scores of the control group were higher than the scores of the patients in all scores in the posturography test, no statistically significant difference was found (p>0.05). In the caloric test, vestibular hypofunction was detected in 7 (53%) of the 13 patients, while there was no participant in the control group with a canal paresis. This difference between the patient and control groups was statistically significant (p<0.05). There was no statistically significant difference between the patient and control groups in terms of anterior, lateral and posterior canal gain rates (p=0.5666). Conclusion: We think that vestibular involvement may be present in Fabry patients, therefore, balance systems should be considered in the treatment and follow-up process of patients
Objective: Fabry disease is the second most common lysosomal storage disorder. Although there are many studies evaluating hearing functions related to this disease in the literature, there are few publications on balance functions. In this study, it was aimed to evaluate vestibular function in Fabry patients. Methods: Thirteen Fabry patients and 14 age-sex matched healthy controls were included in the study. Videonystagmography (VNG), Video Head Impulse Test (v-HIT), Posturography tests were performed together with otoscopic examination and vestibular system examination in both groups. Results: Of the Fabry patients included in the study, 7 (53.8%) were female and 6 (46.1%) were male. In the control group, 5 (35.7%) were female and 9 (64.2%) were male. Although the scores of the control group were higher than the scores of the patients in all scores in the posturography test, no statistically significant difference was found (p>0.05). In the caloric test, vestibular hypofunction was detected in 7 (53%) of the 13 patients, while there was no participant in the control group with a canal paresis. This difference between the patient and control groups was statistically significant (p<0.05). There was no statistically significant difference between the patient and control groups in terms of anterior, lateral and posterior canal gain rates (p=0.5666). Conclusion: We think that vestibular involvement may be present in Fabry patients, therefore, balance systems should be considered in the treatment and follow-up process of patients
Açıklama
Anahtar Kelimeler
VNG, Fabry hastalığı, Vestibüler, Denge, VNG, Fabry disease, Vestibular function, Posturography
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Mutaf, M, (2021). Fabry hastalarında vestibüler fonksiyonun değerlendirilmesi. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Cerrahi Tıp Bilimleri Bölümü Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Konya.
