Serum levels of soluble urokinase plasminogen activator receptor as a new inflammatory marker in adolescent obesity

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dc.contributor.authorCan, Ummugulsum
dc.contributor.authorBuyukinan, Muammer
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.date.accessioned2024-02-23T14:37:48Z
dc.date.available2024-02-23T14:37:48Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground & objectives: Obesity is known for low-grade inflammatory state with enhanced production of inflammatory mediators in children and adolescents. Soluble urokinase plasminogen activator receptor (suPAR) can be generated as a pro-inflammatory marker. This study was conducted to evaluate the role of suPAR, and its association with leptin, adiponectin, interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP) and fibrinogen in adolescent obesity. Methods: A total of 98 participants, 55 obese individuals and 43 healthy controls, aged between 10 and 17 yr, were included in the study. Serum suPAR, IL-6, leptin and adiponectin were measured using ELISA method. Results: Serum suPAR, IL-6, fibrinogen, hsCRP and leptin levels in obese individuals were significantly higher than those of controls (P < 0.05 & P < 0.001). Serum adiponectin levels in obese individuals were significantly lower than those of controls (P < 0.01). Interpretation & conclusions: Our findings showed that suPAR, IL-6, fibrinogen, hsCRP and leptin were significantly higher in the obese individuals than those of controls. suPAR may be a good novel biomarker for systemic subclinical inflammation and immune activation linked to adolescent obesity.en_US
dc.description.sponsorshipKonya Education and Research Hospital, Konya, Turkeyen_US
dc.description.sponsorshipThis study was financially supported by Konya Education and Research Hospital, Konya, Turkey.en_US
dc.identifier.doi10.4103/ijmr.IJMR_1195_15
dc.identifier.endpage333en_US
dc.identifier.issn0971-5916
dc.identifier.pmid28749394en_US
dc.identifier.scopus2-s2.0-85026844617en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage327en_US
dc.identifier.urihttps://doi.org/10.4103/ijmr.IJMR_1195_15
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16244
dc.identifier.volume145en_US
dc.identifier.wosWOS:000406918700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibrinogenen_US
dc.subjectHigh-Sensitive C-Reactive Proteinen_US
dc.subjectInflammationen_US
dc.subjectObesityen_US
dc.subjectSoluble Urokinase Plasminogen Activator Receptoren_US
dc.titleSerum levels of soluble urokinase plasminogen activator receptor as a new inflammatory marker in adolescent obesityen_US
dc.typeArticleen_US

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