Fas/FasL gene polymorphism in patients with Hashimoto's thyroiditis in Turkish population

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dc.contributor.authorErdogan, M.
dc.contributor.authorKulaksizoglu, M.
dc.contributor.authorGanidagli, S.
dc.contributor.authorBerdeli, A.
dc.date.accessioned2024-02-23T14:00:11Z
dc.date.available2024-02-23T14:00:11Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractObjective Hashimoto's disease is a polygenic disorder with complex etiopathogenesis. Apoptosis is proposed as one of its mechanisms. The Fas/Fas ligand cascade represents a major pathway initiating apoptosis. This study aims to evaluate the influence of Fas and FasL gene polymorphism in Hashimoto's thyroiditis in Turkish population. Materials and methods A total of 112 patients with Hashimoto's thyroiditis and 112 cases of healthy control people were included in this study. The evaluation of genotype for Fas -670 A/G and FasL 843 C/T gene polymorphism was performed by using PCR-RFLP method. Results The FAS genotype and gene allele frequency distribution did differ between the control group (AA 36.6 %, AG 50.0 %, GG 13.4 %, A 61.6 %, G 38.4 %) and the Hashimoto's thyroiditis patients (AA 21.4 %, AG 50.9 %, GG 27.7 %, A 46.9 %, G 53.1 %) (p < 0.01). The evaluation of FasL genotype and gene allele frequency did not show statistically significant difference between the patient group (CC 27.7 %, CT 45.5 %, TT 26.8 %, C 50.4 %, T 49.6 %) and control group (CC 33.9 %, CT 44.6 %, TT 21,4 %, C 56.3 %, T 43.8 %) ( p > 0.05). Conclusions Gene polymorphism of Fas and G allele frequency may play a role in the regulation of apoptosis in thyroid autoimmune disorders. There is a need for further studies to clarify the genetic role of apoptosis in HT.en_US
dc.identifier.doi10.1007/s40618-016-0534-5
dc.identifier.endpage82en_US
dc.identifier.issn1720-8386
dc.identifier.issue1en_US
dc.identifier.pmid27572459en_US
dc.identifier.scopus2-s2.0-85007529897en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.1007/s40618-016-0534-5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11487
dc.identifier.volume40en_US
dc.identifier.wosWOS:000391430700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFas/Faslen_US
dc.subjectGene Polymorphismen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.titleFas/FasL gene polymorphism in patients with Hashimoto's thyroiditis in Turkish populationen_US
dc.typeArticleen_US

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