Exploring the biophysical properties of phytosterols in the plasma membrane for novel cancer prevention strategies

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dc.contributor.authorFakih, Omar
dc.contributor.authorSanver, Didem
dc.contributor.authorKane, David
dc.contributor.authorThorne, James L.
dc.date.accessioned2024-02-23T14:02:13Z
dc.date.available2024-02-23T14:02:13Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractCancer is a global problem with no sign that incidences are reducing. The great costs associated with curing cancer, through developing novel treatments and applying patented therapies, is an increasing burden to developed and developing nations alike. These financial and societal problems will be alleviated by research efforts into prevention, or treatments that utilise off-patent or repurposed agents. Phytosterols are natural components of the diet found in an array of seeds, nuts and vegetables and have been added to several consumer food products for the management of cardio-vascular disease through their ability to lower LDL-cholesterol levels. In this review, we provide a connected view between the fields of structural biophysics and cellular and molecular biology to evaluate the growing evidence that phytosterols impair oncogenic pathways in a range of cancer types. The current state of understanding of how phytosterols alter the biophysical properties of plasma membrane is described, and the potential for phytosterols to be repurposed from cardio-vascular to oncology therapeutics. Through an overview of the types of biophysical and molecular biology experiments that have been performed to date, this review informs the reader of the molecular and biophysical mechanisms through which phytosterols could have anti-cancer properties via their interactions with the plasma cell membrane. We also outline emerging and under-explored areas such as computational modelling, improved biomimetic membranes and ex vivo tissue evaluation. Focus of future research in these areas should improve understanding, not just of phytosterols in cancer cell biology but also to give insights into the interaction between the plasma membrane and the genome. These fields are increasingly providing meaningful biological and clinical data but iterative experiments between molecular biology assays, biosynthetic membrane studies and computational membrane modelling improve and refine our understanding of the role of different sterol components of the plasma membrane. (c) 2018 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.en_US
dc.description.sponsorshipSchool of Food Science and Nutrition at the University of Leeds; Breast Cancer Research Action Group part of the Leeds Charitable Foundation [3T57/9R17-02]; Breast Cancer UK [RF_MA_Oxy/PO 1605-382]en_US
dc.description.sponsorshipDr Thorne is supported by the School of Food Science and Nutrition at the University of Leeds and through generous research grants from Breast Cancer Research Action Group [Reference Number: 3T57/9R17-02] which is part of the Leeds Charitable Foundation, and Breast Cancer UK [Reference Number: RF_MA_Oxy/PO 1605-382].en_US
dc.identifier.doi10.1016/j.biochi.2018.04.028
dc.identifier.endpage161en_US
dc.identifier.issn0300-9084
dc.identifier.issn1638-6183
dc.identifier.pmid29730298en_US
dc.identifier.scopus2-s2.0-85047196803en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage150en_US
dc.identifier.urihttps://doi.org/10.1016/j.biochi.2018.04.028
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11632
dc.identifier.volume153en_US
dc.identifier.wosWOS:000446007300015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiochimieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCancer Chemopreventionen_US
dc.subjectDiet And Nutritionen_US
dc.subjectPhytosterolsen_US
dc.subjectMembrane Biophysicsen_US
dc.subjectOncogenic Signallingen_US
dc.subjectLipid Raftsen_US
dc.titleExploring the biophysical properties of phytosterols in the plasma membrane for novel cancer prevention strategiesen_US
dc.typeReview Articleen_US

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