Green and eco-friendly biosynthesis of zinc oxide nanoparticles using Calendula officinalis flower extract: Wound healing potential and antioxidant activity

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dc.contributor.authorAcar, Cigdem Aydin
dc.contributor.authorGencer, Muhammet Abdurrahim
dc.contributor.authorPehlivanoglu, Suray
dc.contributor.authorYesilot, Sukriye
dc.contributor.authorDonmez, Soner
dc.date.accessioned2024-02-23T14:24:17Z
dc.date.available2024-02-23T14:24:17Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractThis study aimed to produce zinc oxide nanoparticles with Calendula officinalis flower extract (Co-ZnO NPs) using the green synthesis method. In addition, the antioxidant and wound healing potential of synthesized ZnO NPs were evaluated. The absorbance band at 355 nm, which is typical for ZnO NPs, was determined from the UV-Vis absorbance spectrum. The energy-dispersive X-ray spectroscopy (EDS) measurements revealed a high zinc content of 42.90%. The x-ray diffractometer data showed Co-ZnO NPs with an average crystallite size of 17.66 nm. The Co-ZnO NPs did not have apparent cytotoxicity up to 10 mu g/mL (IC50 25.96 mu g/mL). C. officinalis ZnO NPs showed partial cell migration and percent wound closure (69.1%) compared with control (64.8%). In addition, antioxidant activities of Co-ZnO NPs with 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2 diphenyl-1 picrylhydrazil (DPPH) were evaluated and radical scavenging activity of 33.49% and 46.63%, respectively, was determined. These results suggest that C. officinalis extract is an effective reducing agent for the green synthesis of ZnO NPs with significant antioxidant and wound healing potential.en_US
dc.description.sponsorshipThis research was supported by the Burdur Mehmet Akif Ersoy University Scientific Research Projects Unit (Project number: 0792-YL-21). The authors are thankful to Suleyman Demirel University YETEM-Innovative Applications and Research Center. [0792-YL-21]; Burdur Mehmet Akif Ersoy University Scientific Research Projects Unit; Suleyman Demirel University YETEM-Innovative Applications and Research Centeren_US
dc.description.sponsorshipThis research was supported by the Burdur Mehmet Akif Ersoy University Scientific Research Projects Unit (Project number: 0792-YL-21). The authors are thankful to Suleyman Demirel University YETEM-Innovative Applications and Research Center.en_US
dc.identifier.doi10.1111/iwj.14413
dc.identifier.issn1742-4801
dc.identifier.issn1742-481X
dc.identifier.pmid37722846en_US
dc.identifier.scopus2-s2.0-85171363988en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/iwj.14413
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13893
dc.identifier.wosWOS:001069292400001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Wound Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectCalendula Officinalisen_US
dc.subjectGreen Synthesisen_US
dc.subjectWound Healingen_US
dc.subjectZinc Oxide Nanoparticlesen_US
dc.titleGreen and eco-friendly biosynthesis of zinc oxide nanoparticles using Calendula officinalis flower extract: Wound healing potential and antioxidant activityen_US
dc.typeArticleen_US

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