Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis

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dc.contributor.authorBaser, Husniye
dc.contributor.authorCan, Ummugulsum
dc.contributor.authorBaser, Salih
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorAslan, Uysaler
dc.contributor.authorHidayetoglu, Bahauddin Taha
dc.date.accessioned2024-02-23T13:59:43Z
dc.date.available2024-02-23T13:59:43Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractOxidative stress results from either overproduction of free radicals or insufficiency of several antioxidant defense systems. It leads to oxidation of main cellular macromolecules and a resultant molecular dysfunction. Thyroid hormones regulate oxidative metabolism and, thus, play a role in free radical production. Studies evaluating oxidative stress in patients with hypothyroidism and hyperthyroidism have been encountered in recent years; however, oxidative status in patients with euthyroid autoimmune thyroiditis (AIT) was not investigated previously. Thirty-five subjects with euthyroid AIT and 35 healthy controls were enrolled in the study. Serum oxidative status was determined by the measurement of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and oxidized-low density lipoprotein (ox-LDL) levels. Serum TAS levels were significantly lower (p < 0.001), while serum TOS levels and IMA levels were significantly higher (p < 0.001 and p = 0.020, respectively) in patients compared to controls. In both groups, ox-LDL levels were similar (p = 0.608). Serum TAS levels were negatively correlated with antithyroid peroxidase and anti-thyroglobulin (anti-TG) levels (rho = -0.415, p = 0.001 and rho = -0.484, p < 0.001, respectively). Serum TOS was positively correlated with anti-TG levels (rho = 0.547, p < 0.001). Further, TAS was positively correlated with free T4 levels (r = 0.279, p = 0.043). No correlation was observed between thyrotropin, free T3 levels, and TOS and TAS levels. These results suggest that oxidants are increased, and anti-oxidants are decreased in patients with euthyroid AIT, and oxidative/anti-oxidative balance is shifted to the oxidative side. Increased oxidative stress might have a role in thyroid autoimmunity.en_US
dc.identifier.doi10.1007/s12020-014-0399-3
dc.identifier.endpage923en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue3en_US
dc.identifier.pmid25150037en_US
dc.identifier.scopus2-s2.0-84925639823en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage916en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-014-0399-3
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11299
dc.identifier.volume48en_US
dc.identifier.wosWOS:000351661100024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEuthyroiden_US
dc.subjectAutoimmune Thyroiditisen_US
dc.subjectOxidative Stressen_US
dc.titleAssesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditisen_US
dc.typeArticleen_US

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