Enzymatic Debridement in Necrotizing Pancreatitis

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dc.contributor.authorCakir, Murat
dc.contributor.authorTekin, Ahmet
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorVatansev, Husamettin
dc.contributor.authorKartal, Adil
dc.date.accessioned2024-02-23T14:44:57Z
dc.date.available2024-02-23T14:44:57Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractMultiple organ failure and pancreatic necrosis are the factors that determine prognosis in acute pancreatitis attacks. We investigated the effects of collagenase on the debridement of experimental pancreatic necrosis. The study covered 4 groups; each group had 10 rats. Group I was the necrotizing pancreatitis group. Group II was the collagenase group with pancreatic loge by isotonic irrigation following necrotizing pancreatitis. Group III was the collagenase group with pancreatic loge following necrotizing pancreatitis. Group IV was the intraperitoneal collagenase group following necrotizing pancreatitis. The progress of the groups was compared hematologically and histopathologically. There was no difference among the groups regarding the levels of leukocyte, hemogram, and urea. The differences in AST levels between Group I and II; and differences in glucose, calcium, LDH, AST, and amylase between Group II and III; between Group II and IV; between Group I and III; and between Group I and IV were statistically significant (P < 0.05). There were statistically significant differences between Group II and III, and Group II and IV regarding edema, acinar necrosis, inflammatory cell infiltration, hemorrhage, and fat necrosis (P < 0.05). In conclusion, the collagenase preparation used in this experimental pancreatitis model was found to be effective in the debridement of pancreatic necrosis.en_US
dc.identifier.doi10.9738/INTSURG-D-14-00164.1
dc.identifier.endpage902en_US
dc.identifier.issn0020-8868
dc.identifier.issue5en_US
dc.identifier.pmid26011212en_US
dc.identifier.scopus2-s2.0-84974824434en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage897en_US
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-14-00164.1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17163
dc.identifier.volume100en_US
dc.identifier.wosWOS:000355193300020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt College Of Surgeonsen_US
dc.relation.ispartofInternational Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectNecroseen_US
dc.subjectCollagenaseen_US
dc.subjectDebridementen_US
dc.titleEnzymatic Debridement in Necrotizing Pancreatitisen_US
dc.typeArticleen_US

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