The role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy study

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dc.contributor.authorSert, Ibrahim Unal
dc.contributor.authorKilic, Ozcan
dc.contributor.authorAkand, Murat
dc.contributor.authorSaglik, Lutfi
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorErdemli, Esra
dc.date.accessioned2024-02-23T14:40:54Z
dc.date.available2024-02-23T14:40:54Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Bisphosphonates are widely used in metastatic cancer such as prostate and breast cancer, and their nephrotoxic effects have been established previously. In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy. Material and methods: A total of 30 male Sprague-Dawley rats were divided into 3 groups. The first group constituted the control group. The second group was given i.v. ZA of 3 mg/kg once every 3 weeks for 12 weeks from the tail vein. The third group received the same dosage of ZA with an additional i.m. injection of 15 mg Vit-E every week for 12 weeks. Tissues were taken 4 days after the last dose of ZA for histopathological and ultrastructural evaluation. Paller score, tubular epithelial thickness and basal membrane thickness were calculated for each group. Results: For group 2, the p-values are all < 0.001 for Paller score, epitelial thickness, and basal membrane thickness. For group 3 (ZA + Vit. E), the p-values are < 0.001 for Paller score, 0.996 for epitelial thickness, and < 0.001 basal membrane thickness. Significant differences were also observed in ultrastructural changes for group 2. However, adding Vit-E to ZA administration reversed all the histopathological changes to some degree, with statistical significance. Conclusions: Administration of ZA had nephrotoxic effects on rat kidney observed under both light and electron microscopy. Concomitant administration of Vit-E significantly reduces toxic histopathological effects of ZA.en_US
dc.identifier.doi10.5114/aoms.2016.60227
dc.identifier.endpage387en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue2en_US
dc.identifier.pmid29593813en_US
dc.identifier.scopus2-s2.0-85043469722en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2016.60227
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16638
dc.identifier.volume14en_US
dc.identifier.wosWOS:000433028600017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectZoledronic Aciden_US
dc.subjectVitamin Een_US
dc.subjectNephrotoxicityen_US
dc.subjectRenal Functionen_US
dc.subjectRaten_US
dc.titleThe role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy studyen_US
dc.typeArticleen_US

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