Does Vitamin D Replacement Alter the Chemotherapy Outcome in Lung Cancer

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dc.contributor.authorAraz, Murat
dc.contributor.authorBeypinar, Ismail
dc.contributor.authorBeypinar, Dilek
dc.contributor.authorDemir, Hacer
dc.contributor.authorUysal, Mukremin
dc.date.accessioned2024-02-23T14:29:37Z
dc.date.available2024-02-23T14:29:37Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractObjectives: Lung cancer accounts for 20% of cancer-related deaths worldwide. Several studies have shown that Vitamin D levels at the time of diagnosis are prognostic in lung cancer. In this study, we evaluated the relationship between pre-diagnosis Vitamin D replacement levels and platinum-based chemotherapy results. Methods: In this cross-sectional study, we retrospectively analyzed archive records of all 247 patients diagnosed with lung cancer from an oncology center in Turkey, between 2012-2018.The chemotherapy outcomes, Vitamin D levels and replacement doses of these patients up to 6 months ago were recorded. Results: Vita min D levels of 153 patients were below 15 ng/mL, 65 patients had a level of 15-30 ng/mL, and 29 patients had a vitamin D level higher than 30 ng/mL. In the study population, 215 had a replacement below 300.000 IU whereas 32 had a replacement above 300.000 IU. When the patients were evaluated based on their chemotherapy responses, no difference was observed between the patients with below and above 300.000 IU. In our study, Vitamin D and replacement level at the time of diagnosis did not change the chemotherapy response. Conclusion: Vita min D replacement levels were not significantly associated with chemotherapy outcomes in our study.en_US
dc.identifier.doi10.14744/ejmo.2019.31913
dc.identifier.endpage115en_US
dc.identifier.issn2587-196X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85168369469en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.14744/ejmo.2019.31913
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14773
dc.identifier.volume3en_US
dc.identifier.wosWOS:000604247700005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofEurasian Journal Of Medicine And Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemotherapy Responseen_US
dc.subjectLung Canceren_US
dc.subjectPrognosisen_US
dc.subjectVitamin Den_US
dc.titleDoes Vitamin D Replacement Alter the Chemotherapy Outcome in Lung Canceren_US
dc.typeArticleen_US

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