Analysis of genetic polymorphisms associated with intervertebral disc degeneration

Basit Öğe Kaydı
dc.contributor.authorKitis, Serkan
dc.contributor.authorCoskun, Zeynep Mine
dc.contributor.authorTasdemir, Pelin
dc.contributor.authorTuncez, Ebru
dc.contributor.authorZamani, Ayse Gul
dc.contributor.authorAcar, Aynur
dc.date.accessioned2024-02-23T14:29:35Z
dc.date.available2024-02-23T14:29:35Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractIntervertebral disc degeneration (IVDD) is a common degenerative spinal condition. Recent studies have shown that the incidence of disc herniation and disc degeneration may be explained by genetic factors. In this study, we investigated the link between various polymorphic variants of the vitamin D receptor (VDR), matrix metalloproteinase 2 (MMP2), and insulin like growth factor 1 receptor (IGF1R) genes and IVDD in patients with IVDD, in Turkey. We examined and genotyped 199 patients with IVDD and 197 healthy individuals. Genomic DNA was isolated from the peripheral blood leukocytes of all participants, and analyzed using real-time PCR. Via melting curve analysis, VDR, MMP2, and IGF1R polymorphism variant distributions were determined. The patients with IVDD showed higher frequencies of the VDR ApaI A allele genotype as compared to the control group; however, there were no significant differences in the frequencies or allelic distributions of the IGF1R and MMP2 genotypes between the IVDD patients and the control group. The incidence of IVDD in these Turkish patients is correlated with the VDR ApaI gene polymorphism, but not with the IGF1R and MMP2 polymorphisms.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Necmettin Erbakan University [131218001]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit of Necmettin Erbakan University; Project No: 131218001.en_US
dc.identifier.doi10.14715/cmb/2018.64.10.10
dc.identifier.endpage65en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue10en_US
dc.identifier.pmid30084796en_US
dc.identifier.scopus2-s2.0-85051755690en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2018.64.10.10
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14749
dc.identifier.volume64en_US
dc.identifier.wosWOS:000443253900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular And Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInsulin Like Growth Factor 1 Receptoren_US
dc.subjectIntervertebral Disc Degenerationen_US
dc.subjectMatrix Metalloproteinase-2en_US
dc.subjectPolymorphismen_US
dc.subjectVitamin D Receptoren_US
dc.titleAnalysis of genetic polymorphisms associated with intervertebral disc degenerationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu