Melatonin Attenuates Contrast-Induced Nephropathy in Diabetic Rats: The Role of Interleukin-33 and Oxidative Stress

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dc.contributor.authorOnk, Didem
dc.contributor.authorOnk, Oruc Alper
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorErol, Huseyin Serkan
dc.contributor.authorAyazoglu, Tulin Akarsu
dc.contributor.authorKeles, Osman Nuri
dc.contributor.authorHalici, Mesut
dc.date.accessioned2024-02-23T14:26:31Z
dc.date.available2024-02-23T14:26:31Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackground. Inflammation and oxidative stress (OxS) contribute to the pathogenesis of diabetic kidney disease (DKD) and contrastinduced nephropathy (CIN). Patients with DKD were found to be more prone to CIN. Interleukin-33 (IL-33) is a proinflammatory cytokine, but its role in DKDand CINis unknown. Methods. Thirty male Sprague-Dawley rats were enrolled. The first group was comprised of healthy rats (HRs), whereas the other four groups were made up of diabetic rats (DRs), diabetic rats with contrastinduced nephropathy (CIN + DRs), melatonin-treated diabetic rats (MTDRs), andmelatonin-treated CIN + DRs (MTCIN + DRs). All groups except the HRs received 50mg/kg/day streptozotocin (STZ). CIN + DRs were constituted by administrating 1.5mg/kg of intravenous radiocontrast dye on the 35th day. MTDRs andMTCIN + DRs were given 20mg/kg/day of intraperitoneal injection of melatonin (MT) from the 28th day for the constitutive seven days. Results. We observed increased IL-33 in the kidney tissue following induction of CIN in DRs. To determine whether MT is effective in preventing CIN, we administered MT in CIN + DRs and demonstrated that kidney tissue levels of OxS markers, inflammatory cytokines, and IL-33 were significantly diminished in MTCIN + DRs compared with other groups without MT treatment (p < 0.05). Conclusion. Inhibition of IL-33 with MT provides therapeutic potential in DKD with CIN.en_US
dc.description.sponsorshipScientific Research Project Foundation of Erzincan University [105/2013]en_US
dc.description.sponsorshipThis project was supported by the Scientific Research Project Foundation of Erzincan University (Project no. 105/2013).en_US
dc.identifier.doi10.1155/2016/9050828
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.pmid26989334en_US
dc.identifier.scopus2-s2.0-84959468446en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2016/9050828
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14232
dc.identifier.volume2016en_US
dc.identifier.wosWOS:000371025700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofMediators Of Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleMelatonin Attenuates Contrast-Induced Nephropathy in Diabetic Rats: The Role of Interleukin-33 and Oxidative Stressen_US
dc.typeArticleen_US

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