Is serum high-mobility group box 1 (HMGB-1) level correlated with liver fibrosis in chronic hepatitis B?

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dc.contributor.authorInkaya, Ahmet Cagkan
dc.contributor.authorDemir, Nazlim Aktug
dc.contributor.authorKolgelier, Servet
dc.contributor.authorSumer, Sua
dc.contributor.authorDemir, Lutfi Saltuk
dc.contributor.authorUral, Onur
dc.contributor.authorPehlivan, Fatma Seher
dc.date.accessioned2024-02-23T14:21:13Z
dc.date.available2024-02-23T14:21:13Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: High-mobility group box 1 (HMGB1), identified as an alarmin molecule, was shown to have a role in virus-triggered liver injury. We aimed to evaluate the association between serum levels of HMGB1 and liver fibrosis. Method: This cross-sectional case-control study included 189 chronic hepatitis B (CHB) patients and 51 healthy controls. All patients underwent liver biopsy and modified Knodell scoring system used to determine the fibrosis level in CHB patients. Serum HMGB1 levels were determined with enzyme-linked immunosorbent assay (ELISA). Results: Mean serum HMGB1 levels of patients (58.1 +/- 54.7) were found to be higher than those of the control group (7.1 +/- 4.3) (P=. 001). HMGB1 levels of patients with advanced-stage fibrosis (stage 4 and 5) were detected to be higher than those of patients with early-stage fibrosis (stage 1-3). However, this difference was not statistically significant (P>. 05). Albumin levels of fibrosis 3 and 4 patients were lower than fibrosis 1 and 2 patients. ALT, HBV DNA, and AFP levels of fibrosis 5 patients were significantly higher than fibrosis 1 and 2 patients, and their platelet and albumin levels are lower than fibrosis 1 and 2 patients (P<. 001). In a logistic regression model, fibrosis levels were correlated with ALT values and inversely correlated with albumin levels. Conclusion: In this study, we demonstrated that serum HMGB1 levels increase in the early course of liver injury and this increase is not correlated with severity of the liver damage.en_US
dc.identifier.doi10.1097/MD.0000000000007547
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue36en_US
dc.identifier.pmid28885322en_US
dc.identifier.scopus2-s2.0-85028998790en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000007547
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13502
dc.identifier.volume96en_US
dc.identifier.wosWOS:000409904600002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlarmin Moleculesen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectHigh-Mobility Group Box 1en_US
dc.subjectLiver Fibrosisen_US
dc.titleIs serum high-mobility group box 1 (HMGB-1) level correlated with liver fibrosis in chronic hepatitis B?en_US
dc.typeArticleen_US

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