Prognostic biomarkers in metastatic colorectal cancer: delta prognostic nutritional index, delta neutrophil to lymphocyte ratio, and delta platelet to lymphocyte ratio

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dc.contributor.authorKocak, Mehmet Zahid
dc.contributor.authorCoban, Seda
dc.contributor.authorAraz, Murat
dc.contributor.authorEryilmaz, Melek Karakurt
dc.contributor.authorArtac, Mehmet
dc.date.accessioned2024-02-23T13:55:50Z
dc.date.available2024-02-23T13:55:50Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackgroundThe aim of this study is to determine the prognostic value of the prognostic nutritional index (PNI), the neutrophil to lymphocyte ratio (NLR), and the platelet to lymphocyte ratio (PLR) and their dynamic changes on survival outcomes in metastatic colorectal cancers (mCRC).MethodsThe data of 199 patients with mCRC were retrospectively analyzed. To evaluate the temporal relation between the PNI, NLR, and PLR values and survival, pre-chemotherapy PNI, NLR, and PLR levels were assessed from peripheral blood cell counts on admission; post-chemotherapy PNI, NLR, and PLR levels were assessed with follow-up blood cell counts within two weeks after chemotherapy; and the difference between pre-chemotherapy PNI, NLR, and PLR levels and post-chemotherapy PNI, NLR, and PLR levels was evaluated as delta PNI, delta NLR, and delta PLR.ResultsThe median PNI, PLR, and NLR were 39.01, 150.2 and 2.53 before chemotherapy and 38.2, 146.6, and 3.31 after chemotherapy, respectively. The median OS was 23.7 months (95%CI:17.8-29.7) and 28.9 months (95%CI:24.8-33.08) for pre-chemotherapy PNI level < 39.01 vs. PNI level >= 39.01, respectively(p = 0.035) The positive delta PNI was significantly higher for OS than the negative delta PNI(p < 0.009). Delta PLR and delta NLR were not significant for OS and PFS(p > 0.05 for all).ConclusionsThe results of this study clearly show that the negative delta PNI to be an independent predictor of poor OS and poor PFS in patients with colon cancer who received first line treatment. In addition, delta NLR and delta PLR were shown not to predict survival outcomes.en_US
dc.identifier.doi10.1007/s00520-023-07829-w
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue6en_US
dc.identifier.pmid37246994en_US
dc.identifier.scopus2-s2.0-85160310252en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00520-023-07829-w
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10975
dc.identifier.volume31en_US
dc.identifier.wosWOS:000998719700004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSupportive Care In Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrognostic Nutritional Indexen_US
dc.subjectNeutrophil To Lymphocyte Ratioen_US
dc.subjectPlatelet To Lymphocyte Ratioen_US
dc.subjectDeltaen_US
dc.subjectMetastatic Colon Canceren_US
dc.titlePrognostic biomarkers in metastatic colorectal cancer: delta prognostic nutritional index, delta neutrophil to lymphocyte ratio, and delta platelet to lymphocyte ratioen_US
dc.typeArticleen_US

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