The effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adults

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dc.contributor.authorPeker, Kevser
dc.contributor.authorOkesli, Selmin
dc.contributor.authorKiyici, Aysel
dc.contributor.authorDeyisli, Cemile
dc.date.accessioned2024-02-23T14:41:39Z
dc.date.available2024-02-23T14:41:39Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: The primary aim of this study was to compare the effects of a small-dose infusion of 2 antioxidant agents, ketamine and lidocaine, on ischemia-reperfusion injury (IRI) in patients undergoing elective lower limb surgery. Ischemia-modified albumin (IMA), lactate, and blood gas levels were all measured and assessed. METHODS: A total of 100 patients who underwent lower extremity surgery were randomized into 3 groups. After spinal anesthesia, the ketamine group (Group K, n= 33) was given a ketamine infusion, a lidocaine infusion was administered to the lidocaine group (Group L, n= 33), and in the control group (Group C), 0.9% a sodium chloride infusion was performed. Blood samples were obtained for IMA analysis before anesthetic administration (baseline), at 30 minutes of tourniquet inflation (ischemia), and 15 minutes after tourniquet deflation (reperfusion). Arterial blood gas measurements were determined before anesthetic administration and 15 minutes after tourniquet deflation. RESULTS: The lactate and IMA levels at reperfusion were significantly lower in both the ketamine group and the lidocaine group when compared with the control group. CONCLUSION: The administration of both ketamine and lidocaine infusions significantly decreased skeletal muscle IRI-related high lactate and IMA levels. These results suggest the possibility of the clinical application of ketamine or lidocaine infusions in cases of skeletal muscle-related IRI.en_US
dc.identifier.doi10.5505/tjtes.2018.63439
dc.identifier.endpage117en_US
dc.identifier.issn1306-696X
dc.identifier.issue2en_US
dc.identifier.pmid30892676en_US
dc.identifier.scopus2-s2.0-85063262324en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2018.63439
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16948
dc.identifier.volume25en_US
dc.identifier.wosWOS:000461479100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia Reperfusion Injuryen_US
dc.subjectKetamineen_US
dc.subjectLidocaineen_US
dc.titleThe effects of ketamine and lidocaine on free radical production after tourniquet-induced ischemia-reperfusion injury in adultsen_US
dc.typeArticleen_US

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