Graphene-based hybrid for enantioselective sensing applications

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dc.contributor.authorZor, Erhan
dc.contributor.authorMorales-Narvaez, Eden
dc.contributor.authorAlpaydin, Sabri
dc.contributor.authorBingol, Haluk
dc.contributor.authorErsoz, Mustafa
dc.contributor.authorMerkoci, Arben
dc.date.accessioned2024-02-23T14:02:15Z
dc.date.available2024-02-23T14:02:15Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractChirality is a major field of research of chemical biology and is essential in pharmacology. Accordingly, approaches for distinguishing between different chiral forms of a compound are of great interest. We report on an efficient and generic enantioselective sensor that is achieved by coupling reduced graphene oxide with gamma-cyclodextrin (rGO/gamma-CD). The enantioselective sensing capability of the resulting structure was operated in both electrical and optical mode for of tryptophan enantiomers (D-/L-Trp). In this sense, voltammetric and photoluminescence measurements were conducted and the experimental results were compared to molecular docking method. We gain insight into the occurring recognition mechanism with selectivity toward D- and L-Trp as shown in voltammetric, photoluminescence and molecular docking responses. As an enantioselective solid phase on an electrochemical transducer, thanks to the different dimensional interaction of enantiomers with hybrid material, a discrepancy occurs in the Gibbs free energy leading to a difference in oxidation peak potential as observed in electrochemical measurements. The optical sensing principle is based on the energy transfer phenomenon that occurs between photo excited D-/L-Trp enantiomers and rGO/gamma-CD giving rise to an enantioselective photoluminescence quenching due to the tendency of chiral enantiomers to form complexes with gamma-CD in different molecular orientations as demonstrated by molecular docking studies. The approach, which is the first demonstration of applicability of molecular docking to show both enantioselective electrochemical and photoluminescence quenching capabilities of a graphene-related hybrid material, is truly new and may have broad interest in combination of experimental and computational methods for enantiosensing of chiral molecules. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAK [113Z664, BIDEB-2214-A/1059B141400210]; MINECO (Spain) [MAT2014-52485-P]; MINECO (Severo Ochoa Program) [SEV-2013-0295]; Secretaria d' Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya [2014 SGR 260]; ICREA Funding Source: Customen_US
dc.description.sponsorshipThis work was supported by TUBITAK (113Z664 and BIDEB-2214-A/1059B141400210) and was produced from a part of E. Zor's Ph.D. thesis. Nanobiosensors and Bioelectronics Group acknowledges the support from MINECO (Spain, MAT2014-52485-P and Severo Ochoa Program, Grant SEV-2013-0295) and Secretaria d' Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya (2014 SGR 260).en_US
dc.identifier.doi10.1016/j.bios.2016.08.074
dc.identifier.endpage416en_US
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.pmid27589404en_US
dc.identifier.scopus2-s2.0-84984629288en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage410en_US
dc.identifier.urihttps://doi.org/10.1016/j.bios.2016.08.074
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11646
dc.identifier.volume87en_US
dc.identifier.wosWOS:000390499600058en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Advanced Technologyen_US
dc.relation.ispartofBiosensors & Bioelectronicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGraphene Oxideen_US
dc.subjectCyclodextrinen_US
dc.subjectEnantioselectivityen_US
dc.subjectSensoren_US
dc.subjectMolecular Dockingen_US
dc.titleGraphene-based hybrid for enantioselective sensing applicationsen_US
dc.typeArticleen_US

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