Elevated survivin levels in patients with acne vulgaris

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dc.contributor.authorAksoy Sarac, Gulhan
dc.contributor.authorKader, Saadet
dc.contributor.authorAkdag, Turan
dc.date.accessioned2024-02-23T14:24:30Z
dc.date.available2024-02-23T14:24:30Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective Acne vulgaris is a multifactorial disease of the pilosebaceous unit. As the most common skin disease, it may affect approximately 85% of the young population. Survivin, a member of the inhibitors of the apoptosis (IAP) gene family, can inhibit apoptosis and regulate cell division and proliferation. In the study, we aimed to investigate the potential role of serum survivin in acne vulgaris. Methods Forty individuals who were diagnosed with acne vulgaris and forty healthy subjects as the control group were enrolled in the study. Venous blood samples were collected from each participant, and the serum levels of survivin were measured by enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed using SPSS software version 25. Results The serum survivin levels were statistically significant between the groups, and the levels of survivin were measured as acne vulgaris patients group 153.44 and control group 104.17 pg/ml, respectively (p < 0.018). When the serum survivin levels were compared according to gender, females had higher levels of survivin than the males (168.16 versus 50.45 pg/mL, p = 0.001). A significant correlation was found between acne severity (p = 0.017) and Scale for Acne Scar severity (SCAR-S) score (p = 0.001) according to the survivin levels. In terms of age, no significant relationship was found between age and survivin (p = 0.4048). Conclusion Elevated serum levels of survivin were determined in acne vulgaris. Moreover, there was a significant correlation between acne stage and SCAR-S score according to survivin levels.en_US
dc.identifier.doi10.1111/jocd.14742
dc.identifier.endpage1748en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue4en_US
dc.identifier.pmid35037363en_US
dc.identifier.scopus2-s2.0-85122749871en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1744en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.14742
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13967
dc.identifier.volume21en_US
dc.identifier.wosWOS:000743068000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcne Scarringen_US
dc.subjectAcne Vulgarisen_US
dc.subjectInflammationen_US
dc.titleElevated survivin levels in patients with acne vulgarisen_US
dc.typeArticleen_US

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