Influence of Cyclopentolate Hydrochloride on Corneal Biomechanical Properties in Healthy Individuals

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dc.contributor.authorOltulu, Refik
dc.contributor.authorSatirtav, Gunhal
dc.contributor.authorKerimoglu, Hurkan
dc.contributor.authorZengin, Nazmi
dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorOkka, Mehmet
dc.date.accessioned2024-02-23T14:21:10Z
dc.date.available2024-02-23T14:21:10Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: This observational study aims to investigate the effects of cyclopentolate hydrochloride (1%) on corneal biomechanical properties, with the ocular response analyzer (ORA), in healthy individuals. Methods: Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) measurements of 36 (15 female and 21 male) healthy individuals, before and after 45 min of 1% cyclopentolate hydrochloride instillation, were performed by the ORA. Results: The mean CH and IOPcc measurements of the eyes were 10.63 +/- 1.17 mm Hg and 15.15 +/- 2.69 mm Hg, precycloplegia, and 11.09 +/- 1.32 mm Hg and 14.16 +/- 2.77 mm Hg, postcycloplegia, respectively. The differences between the precycloplegia and postcycloplegia in both measurements were statistically significant (P=0.031, P=0.016, respectively; paired t test). The mean CRF and mean IOPg measurements of the eyes were 10.40 +/- 1.16 mm Hg and 14.83 +/- 2.56 mm Hg, precycloplegia, and 10.61 +/- 1.33 mm Hg and 14.25 +/- 2.65 mm Hg, postcycloplegia, respectively. The differences between the precycloplegia and postcycloplegia measurements of the eyes were insignificant (P=0.264 and P=0.100, respectively; paired t test). Conclusions: A 1% cyclopentolate hydrochloride instillation leads to significant changes in the CH values and IOPcc measurements. This should be taken into account during the evaluation of refractive surgery candidates and in clinical conditions where ORA measurements are considered in the diagnosis and follow-up.en_US
dc.identifier.doi10.1097/ICL.0000000000000058
dc.identifier.endpage311en_US
dc.identifier.issn1542-2321
dc.identifier.issn1542-233X
dc.identifier.issue5en_US
dc.identifier.pmid25083778en_US
dc.identifier.scopus2-s2.0-85027919486en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://doi.org/10.1097/ICL.0000000000000058
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13457
dc.identifier.volume40en_US
dc.identifier.wosWOS:000341983100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEye & Contact Lens-Science And Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclopentolate Hydrochlorideen_US
dc.subjectOcular Response Analyzeren_US
dc.subjectCorneal Biomechanicsen_US
dc.titleInfluence of Cyclopentolate Hydrochloride on Corneal Biomechanical Properties in Healthy Individualsen_US
dc.typeArticleen_US

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