The relationship of preoperative hematologic parameters to invasion of anatomic structures and recurrence in tenosynovial giant-cell tumor of the digits

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dc.contributor.authorColak, T. S.
dc.contributor.authorOzgezmez, F. T.
dc.contributor.authorKaya, Huseyin
dc.date.accessioned2024-02-23T14:03:01Z
dc.date.available2024-02-23T14:03:01Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAlthough the pathogenesis of Teno- Synovial Giant Cell Tumor (TSGCT) is not known, inflammation is thought to play a role in the etiology beside some other factors. Many researchers have found a close relationship between hematological parameters such as Mean Platelet Volume (MPV), Platelet/MPV Ratio (Plt/MPV), Monocyte/Neutrophil Ratio (MNR), Neutrophil/Lymphocyte Ratio (NLR), Platelet/ Lymphocyte Ratio (PLR) and certain inflammatory, autoimmune and neoplastic diseases. The aim of the present study was to assess the relationship of hematological parameters (NLR, MNR and Plt/MPV) to tumor recurrence and spread after TSGCT surgery. Data from 102 patients who matched the inclusion criteria comprised preoperative hematological parameters, tumor size, anatomic region, side, presence of bone invasion, proximity to joints or neurovascular structures, and postoperative recurrence and complications. The mean follow-up was 54.2 months (similar to 26.5). Recurrence was observed in 12 (11.8%) of the 102 cases. No significant correlation was found between recurrence and hematologic parameter, age, laterality (right-left) or zone (volar-dorsal). There were no significant differences in NLR, Plt/MPV or MNR between patients with and without bone, capsular, nerve or total involvement. The study thus showed that the various inflammatory parameters (NLR, Plt/MPV and MNR) calculated from blood count were not predictive of tumor invasion into anatomical structures or of digital TSGCT recurrence. (c) 2022 SFCM. Published by Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.hansur.2022.04.005
dc.identifier.endpage517en_US
dc.identifier.issn2468-1229
dc.identifier.issn2468-1210
dc.identifier.issue4en_US
dc.identifier.pmid35470001en_US
dc.identifier.scopus2-s2.0-85130333434en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage513en_US
dc.identifier.urihttps://doi.org/10.1016/j.hansur.2022.04.005
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11940
dc.identifier.volume41en_US
dc.identifier.wosWOS:000965875500014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofHand Surgery & Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTenosynovial Giant-Cell Tumoren_US
dc.subjectInflammatory Parametersen_US
dc.subjectRecurrenceen_US
dc.subjectTumor Invasionen_US
dc.titleThe relationship of preoperative hematologic parameters to invasion of anatomic structures and recurrence in tenosynovial giant-cell tumor of the digitsen_US
dc.typeArticleen_US

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