Investigation of the relationship between ischemic stroke and endothelial nitric oxide synthase gene polymorphisms [G894T, intron 4 VNTR and T786C]

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dc.contributor.authorAnliacik, Suleyman Omer
dc.contributor.authorTokgoz, Serhat
dc.contributor.authorZamani, Ayse Gul
dc.contributor.authorYildirim, Malunut Selman
dc.contributor.authorIyisoy, Mehmet Sinan
dc.date.accessioned2024-02-23T14:37:23Z
dc.date.available2024-02-23T14:37:23Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: We aimed to investigate the associations between endothelial nitric oxide synthase (eNOS) gene polymorphisms [G894T (rs1799983)], intron 4 (27-bpTR)variable number tandem repeat (VNTR) and T786C (rs2070744), and ischemic stroke in the Anatolian population. Materials and methods: This case-control study included 112 patients with stroke of undetermined etiology and 160 controls. Real-time polymerase chain reaction (RT-PCR) analysis was used to analyze these polymorphisms. Between-group frequencies of alleles and genotypes were compared using binary logistic regression analysis. Results: No significant difference was observed between the two groups in terms of the genotype and allele distributions of the eNOS G894T (rs1799983) polymorphism (P > 0.05). The a alleles and the 4b/a and 4a/a genotypes of the intron 4 (27-bpTR) VNTR polymorphism had significantly higher frequencies in the patient group than in the control group (OR: 2.715, P < 0.001; OR: 3.396, P < 0.001; OR: 10.631, P = 0.016, respectively). On the contrary, the TC genotype and C alleles of the T786C (rs2070744) polymorphism had a significantly lower frequency in the patient group than in the control group (OR: 0.244, P < 0.001, OR: 0.605, P = 0.006, respectively). Conclusion: Our findings indicate that the eNOS G894T and T786C [rs2070744] polymorphisms are not associated with the risk of ischemic stroke, whereas the intron 4 [27-bpTR] VNTR may be a risk factor in the Anatolian population.en_US
dc.identifier.doi10.3906/sag-1808-57
dc.identifier.endpage594en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid30997974en_US
dc.identifier.scopus2-s2.0-85065079539en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage589en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1808-57
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16082
dc.identifier.volume49en_US
dc.identifier.wosWOS:000465264700021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStrokeen_US
dc.subjectPolymorphismen_US
dc.subjectEndothelial Nitric Oxide Synthaseen_US
dc.subjectG894ten_US
dc.subjectVariable Number Tandem Repeaten_US
dc.subjectT786cen_US
dc.titleInvestigation of the relationship between ischemic stroke and endothelial nitric oxide synthase gene polymorphisms [G894T, intron 4 VNTR and T786C]en_US
dc.typeArticleen_US

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