Assessment of antimutagenic action of Celtis glabrata Steven ex Planch. (Cannabaceae) extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test

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dc.contributor.authorAkin, Duygu
dc.contributor.authorDurak, Yusuf
dc.contributor.authorUysal, Ahmet
dc.contributor.authorGunes, Erdogan
dc.contributor.authorAladag, Mustafa Onur
dc.date.accessioned2024-02-23T14:34:36Z
dc.date.available2024-02-23T14:34:36Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractContext: Celtis glabrata is used in Turkey for the treatment of various health disorders. Objective: The acetone, chloroform, ethanol, and methanol extracts of C. glabrata leaf, fruit, and seed were investigated to evaluate their antimutagenic activities. Material and methods: The antimutagenicity of these extracts was determined by Ames test against mutagens (4-nitro-O-phenylenediamine, 2-aminofluorene (2-AF), and sodium azide (SA)). The extracts were used at concentrations between 5 and 0.005 mg/plate. Results: The ethanol extracts of leaves exhibited strong antimutagenicity (70%) against 2-AF with S9 at 5 mg/plate on TA98. But methanol (61%, 53%) and acetone (53%, 52%) also revealed strong inhibition rates at concentrations of >= 0.5 mg/plate. Among the extracts, the highest activity (96%) was obtained from acetone extract against SA without S9, followed by chloroform extract (91%) at a dose of 5 mg/plate on TA100 with S9. Ethanol (without S9) and chloroform (with S9) extracts showed strong antimutagenicity at all doses. Exception of chloroform and acetone (without S9), all fruit extracts (with/without S9) manifested strong antimutagenicity at doses of >= 0.5 mg/plate on TA98 strain. Ethanol extracts revealed 68% inhibition against 2-AF on TA98. Acetone and ethanol extracts manifested 84% and 82% inhibition against SA on TA100, respectively. All the extracts of seeds revealed strong inhibition against 2-AF at >= 0.5 mg/plate doses on TA98, but acetone extract showed excellent antimutagenicity (94%). Moreover, the chloroform (74, 73, 63, 54%), acetone (74, 72, 70, 65%) and methanol (74, 67, 63, 61%) extracts of seeds revealed strong antimutagenic activity on TA100 against SA with S9. Discussion and conclusion: This plant may be natural source of antimutagenic agents.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordinating Office (BAP) [09201057]en_US
dc.description.sponsorshipWe would like to thank Selcuk University Scientific Research Projects Coordinating Office (BAP) for supporting this project financially (Project No: 09201057).en_US
dc.identifier.doi10.3109/01480545.2015.1121273
dc.identifier.endpage321en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3en_US
dc.identifier.pmid26739110en_US
dc.identifier.scopus2-s2.0-84953210352en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage312en_US
dc.identifier.urihttps://doi.org/10.3109/01480545.2015.1121273
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15651
dc.identifier.volume39en_US
dc.identifier.wosWOS:000373934300012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSalmonella/Microsome Test Systemen_US
dc.subjectFree Radical Scavengingen_US
dc.subjectTotal Phenol Contenten_US
dc.subjectCannabaceaeen_US
dc.subjectAntimutagenicityen_US
dc.titleAssessment of antimutagenic action of Celtis glabrata Steven ex Planch. (Cannabaceae) extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames testen_US
dc.typeArticleen_US

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