Two-Dimensional (2D) materials in the detection of SARS-CoV-2

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dc.contributor.authorUzunoglu, Aytekin
dc.contributor.authorAltuntas, Evrim Gunes
dc.contributor.authorIpekci, Hasan Huseyin
dc.contributor.authorOzoglu, Ozum
dc.date.accessioned2024-02-23T14:13:17Z
dc.date.available2024-02-23T14:13:17Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractThe SARS-CoV-2 pandemic has resulted in a devastating effect on human health in the last three years. While tremendous effort has been devoted to the development of effective treatment and vaccines against SARS-CoV-2 and controlling the spread of it, collective health challenges have been encountered along with the concurrent serious economic impacts. Since the beginning of the pandemic, various detection methods like PCR-based methods, isothermal nucleic acid amplification-based (INAA) methods, serological methods or antibody tests, and evaluation of X-ray chest results have been exploited to diagnose SARS-CoV-2. PCR-based detection methods in these are considered gold standards in the current stage despite their drawbacks, including being high-cost and time-consuming procedures. Furthermore, the results obtained from the PCR tests are susceptible to sample collection methods and time. When the sample is not collected properly, obtaining a false result may be likely. The use of specialized lab equipment and the need for trained people for the experiments pose additional challenges in PCR-based testing methods. Also, similar problems are observed in other molecular and serological methods. Therefore, biosensor technologies are becoming advantageous with their quick response, high specificity and precision, and low-cost characteristics for SARS-CoV-2 detection. In this paper, we critically review the advances in the development of sensors for the detection of SARS-CoV-2 using two-dimensional (2D) materials. Since 2D materials including graphene and graphene-related materials, transition metal carbides, carbonitrides, and nitrides (MXenes), and transition metal dichalcogenides (TMDs) play key roles in the development of novel and high-performance electrochemical (bio)sensors, this review pushes the sensor technologies against SARSCoV-2 detection forward and highlights the current trends. First, the basics of SARS-CoV-2 detection are described. Then the structure and the physicochemical properties of the 2D materials are explained, which is followed by the development of SARS-CoV-2 sensors by exploiting the exceptional properties of the 2D materials. This critical review covers most of the published papers in detail from the beginning of the outbreak.en_US
dc.identifier.doi10.1016/j.microc.2023.108970
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.pmid37342763en_US
dc.identifier.scopus2-s2.0-85164666417en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.microc.2023.108970
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12355
dc.identifier.volume193en_US
dc.identifier.wosWOS:001037228000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMicrochemical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSars-Cov-2en_US
dc.subjectBiosensoren_US
dc.subject2d Materialsen_US
dc.subjectGrapheneen_US
dc.subjectTmdsen_US
dc.subjectMxenesen_US
dc.titleTwo-Dimensional (2D) materials in the detection of SARS-CoV-2en_US
dc.typeArticleen_US

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