Evaluation of transcription factors and cytokine expressions of T-cell subsets in CD19 deficiency and their possible relationship with autoimmune disease

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dc.contributor.authorKueccuektuerk, Serkan
dc.contributor.authorKaraselek, Mehmet Ali
dc.contributor.authorDuran, Tugce
dc.contributor.authorReisli, Ismail
dc.date.accessioned2024-02-23T14:24:02Z
dc.date.available2024-02-23T14:24:02Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractCD19 deficiency is a rare, predominantly antibody deficiency, and there are few studies showing that it can be seen in autoimmune diseases. The aim of study was evaluated to transcription factor and cytokine expressions of helper T (Th)-cell subsets in CD19 deficiency and the possible mechanism role of this factor expression in autoimmune disease. Transcription factor and cytokine expressions of Th1, Th2, Th17, and regulatory T (Treg) cells were investigated by real-time polymerase chain reaction (qPCR) method. In the study, in the patient/control comparison, transcription factor and cytokine expressions of Th1 (T-bet, STAT1, and STAT4) were found to be significantly downregulated, but IFN-gamma was significantly upregulated in patients. Th2 factor GATA3, STAT6, IL-4, and IL-5 were significantly downregulated. For Th17, ROR gamma t was downregulated while IL-22 was upregulated. In the heterozygous/control comparison, there was no significant change in gene expressions other than IL-5. T-bet, STAT1, GATA3, IL-4, ROR gamma t, FoxP3, and TGF-beta were significantly downregulated in the patient/heterozygous comparison. It was revealed for the first time that the expression of the transcription factors and cytokines in CD19 deficiency. These findings might be showing the predominance of Th1 factors and suppressed Treg factors which could be related with autoimmunity in CD19 deficiency.en_US
dc.identifier.doi10.1111/apm.13363
dc.identifier.endpage129en_US
dc.identifier.issn0903-4641
dc.identifier.issn1600-0463
dc.identifier.issue2en_US
dc.identifier.pmid38095318en_US
dc.identifier.scopus2-s2.0-85179682469en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.1111/apm.13363
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13791
dc.identifier.volume132en_US
dc.identifier.wosWOS:001126010300001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofApmisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCd19 Deficiencyen_US
dc.subjectTh1en_US
dc.subjectTh2en_US
dc.subjectTregen_US
dc.titleEvaluation of transcription factors and cytokine expressions of T-cell subsets in CD19 deficiency and their possible relationship with autoimmune diseaseen_US
dc.typeArticleen_US

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