Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk?

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dc.contributor.authorUcar, V. B.
dc.contributor.authorNami, B.
dc.contributor.authorAcar, H.
dc.contributor.authorKilinc, M.
dc.date.accessioned2024-02-23T14:24:01Z
dc.date.available2024-02-23T14:24:01Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractVaricocele is one of the main reasons for male infertility the exact aetiology of which remains unclear. Methylenetetrahydrofolate reductase (MTHFR) is important for DNA synthesis and methylation, which has a key role during spermatogenesis. Numerous literature suggests that the MTHFR polymorphism may be genetic risk factors for male infertility. In this study, we evaluated C677T and A1298CMTHFR gene polymorphism frequency in patients with varicocele and normal men. A total of 107 varicocele patients and 109 fertile healthy individuals were included. Genotyping of the MTHFR gene in C677T and A1298C base pairs carried out by using real-time PCR technique and afterwards, the statistical analysis accomplished. There is a statistical difference for the frequency of 1298AA genotype in patients with varicocele compared with normal controls (P=0.0051, OR=2.2750). Instead, subsequently, 1298/A allel frequency in patient group was significantly higher in comparison with control group (P=0.0174). According to our results, 1298AA genotype in MTHFR gene raises the risk of varicocele approximately 2.3 times more compared with men carrying other genotypes. The results show that genetic factors have an important role in the molecular basis of varicocele.en_US
dc.identifier.doi10.1111/and.12229
dc.identifier.endpage46en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue1en_US
dc.identifier.pmid24456105en_US
dc.identifier.scopus2-s2.0-84920945051en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage42en_US
dc.identifier.urihttps://doi.org/10.1111/and.12229
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13779
dc.identifier.volume47en_US
dc.identifier.wosWOS:000348060100009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMthfr-1298en_US
dc.subjectMthfr-677en_US
dc.subjectPolymorphismen_US
dc.subjectVaricoceleen_US
dc.titleIs methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk?en_US
dc.typeArticleen_US

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