The Relationship Between Serum Zinc Levels and Tumor Markers in Hemodialysis Patients

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dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorEcder, Tevfik
dc.contributor.authorTurk, Suleyman
dc.date.accessioned2024-02-23T14:31:56Z
dc.date.available2024-02-23T14:31:56Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractThe incidence of neoplasia is increased in end-stage renal disease (ESRD) patients. Zinc (Zn) deficiency is associated with neoplasia and also commonly seen in ESRD patients. However, the data regarding the relationship between Zn levels and tumor markers is scant in this population. We aimed to investigate the relationship between Zn levels and tumor markers in hemodialysis patients. Twenty-six hemodialysis patients (11 male, 15 female, mean age 41.6 +/- 14.3 years) and 11 healthy subjects (6 male and 5 female, mean age 38.7 +/- 7.2 years) were included. Serum Alpha fetoprotein (AFP), carcinoembriyonic antigen (CEA), CA 19-9, CA 15-5, CA 125, beta subunit of human corionic gonadotrophin (beta-HCG) and beta-2 microglobulin (beta 2M) and Zn levels were measured. Data were analysed by Student's t test. Serum Zinc levels were significantly lower in ESRD patients (group 1) compared to healthy subjects (group 2) (p<0.0001, for all). Serum CEA and beta 2M levels were also significantly higher in group 1 patients compared to group 2 subjects (p<0.005, p<0.0001, respectively). Serum Ca15-3 and CA-125 levels were found to be significantly lower in group 1 patients compared to group 2 subjects (p<0.005, p<0.001, respectively). There were no statistically significant difference in terms of serum CA 19-9, beta-HCG and AFP between group 1 and group 2 patients. In group 1 patients, there was a negative correlation between serum Zn levels and AFP, while a positive correlation was obsorved between serum Zn levels and CA15-3. The measurement of AFP may be beneficial in HD patients. Further studies are needed.en_US
dc.identifier.doi10.15197/sabad.1.11.65
dc.identifier.endpage178en_US
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84908394626en_US
dc.identifier.startpage174en_US
dc.identifier.urihttps://doi.org/10.15197/sabad.1.11.65
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15424
dc.identifier.volume11en_US
dc.identifier.wosWOS:000421937800008en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherModestum Ltden_US
dc.relation.ispartofEuropean Journal Of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHemodialysisen_US
dc.subjectZincen_US
dc.subjectTumor Markersen_US
dc.titleThe Relationship Between Serum Zinc Levels and Tumor Markers in Hemodialysis Patientsen_US
dc.typeArticleen_US

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