Prognostic value of pre-treatment 18F-FDG-PET uptake in small-cell lung cancer
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose Small-cell lung cancer (SCLC) is an aggressive disease, despite an initially favorable response to treatment, and its prognosis is still poor. Multiple parameters have been studied as possible prognostic factors, but none of them are reliable enough to change the treatment approach. F-18-fluorodeoxyglucose-positron emission tomography (FDG-PET) is a novel imaging technique for staging of SCLC. The aim of this study was to evaluate the prognostic value of pre-treatment FDG-PET parameters on clinical outcome in limited stage (LS) SCLC patients treated with curative thoracic radiotherapy (RT) and chemotherapy. Clinical records of 46 LS-SCLC patients with pre-treatment FDG-PET imaging were retrospectively reviewed. Patients were treated with definitive RT for a total dose of 50-60 Gy and chemotherapy. The clinical endpoints were progression-free survival (PFS) and overall survival (OS). The median age was 59 (range 30-82) years, and median follow-up time was 23.2 months (range 5-82.8 months). Median OS was 30.9 months for pre-treatment tumor maximum standardized uptake value (SUVmax) < 9.3 and 20.6 months for SUVmax ae9.3 (p = 0.027) and PFS was 55.6 months for SUVmax < 9.3 and 38.6 months for SUVmax ae9.3 (p = 0.16). Median OS was 73 months for pre-treatment lymph node SUVmax < 5.8 and 21 months for ae5.8 (p = 0.01) and PFS was 38.6 months (range 6.8-70.3 months) for SUVmax-LN ae5.8; all patients with SUVmax-LN < 5.8 were alive (p = 0.07). Median survival time was 28.2 months (range 21.7-34.7 months) for patients younger than 65 and 8.7 months (range 5.7-11.8 months) for those ae65 years (p = 0.00). Pre-treatment FDG-PET uptake may be a valuable tool to evaluate prognosis in SCLC patients. Patients with a higher pre-treatment FDG uptake may be considered at increased risk of failure and may benefit from more aggressive treatment approaches.
Açıklama
Anahtar Kelimeler
Fdg-Pet, Lung Cancer, Small-Cell Lung Cancer, Prognosis
Kaynak
Annals Of Nuclear Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
31
Sayı
6
