The effect of zinc deficiency and zinc supplementation on element levels in the bone tissue of ovariectomized rats: Histopathologic changes

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dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorSunar, Fusun
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorAcar, Musa
dc.contributor.authorToy, Hatice
dc.date.accessioned2024-02-23T14:34:38Z
dc.date.available2024-02-23T14:34:38Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: Study aimed to determine the effects of zinc supplementation/deficiency on the histological structure and elements levels in bone tissue in ovariectomized rats. Methods: The study included 40 Sprague-Dawley type adult female rats, divided as follows: Control, ovariectomized, ovariectomized + zinc supplemented, ovariectomized + zinc deficient groups. At the end of the study bone tissues (femur) were collected to determine the levels of calcium, phosphorus, magnesium, zinc, iron, aluminium, chrome, lithium, lead, nickel, and manganese. The bone tissue was examined for histopathology. Results: Ovariectomy leaded to significant decrease in magnesium. Zinc supplementation to ovariectomized rats restored the reduced calcium, phosphorus, zinc. However, zinc deficiency in ovariectomized rats further reduced calcium, phosphorus, zinc, and manganese levels. Zinc deficiency in ovariectomized significantly increased Al, Cr, Li, Pb, and Ni levels. Tissue integrity was impaired due to ovariectomy and zinc deficiency. Conclusion: Ovariectomy and zinc deficiency leads significant decreases elements of the bone.en_US
dc.identifier.doi10.3109/13813455.2014.884141
dc.identifier.endpage85en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue2en_US
dc.identifier.pmid24499014en_US
dc.identifier.scopus2-s2.0-84910139246en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.3109/13813455.2014.884141
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15682
dc.identifier.volume120en_US
dc.identifier.wosWOS:000334917900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives Of Physiology And Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBoneen_US
dc.subjectElementsen_US
dc.subjectOvariectomyen_US
dc.subjectZinc Supplementation And Deficiencyen_US
dc.titleThe effect of zinc deficiency and zinc supplementation on element levels in the bone tissue of ovariectomized rats: Histopathologic changesen_US
dc.typeArticleen_US

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