Are dietary and serum advanced glycation end-products related to inflammation and oxidation biomarkers in breast cancer patients: a follow-up study

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dc.contributor.authorAlkan, Senay Burcin
dc.contributor.authorArtac, Mehmet
dc.contributor.authorAksoy, Faruk
dc.contributor.authorBelviranli, Mehmet Metin
dc.contributor.authorGurbilek, Mehmet
dc.contributor.authorCizmecioglu, Hilal Akay
dc.contributor.authorRakicioglu, Neslisah
dc.date.accessioned2024-02-23T13:55:50Z
dc.date.available2024-02-23T13:55:50Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPurposeThis study is aimed at evaluating the relationship between dietary and serum advanced glycation end-products (AGEs) with serum inflammatory and oxidative stress biomarkers in breast cancer (BC).MethodsA sample of BC patients was followed for 12 months (March 2020-January 2022). Three-day food consumption record and serum samples were taken before surgery (T1), before chemotherapy (T2), at the 6(th) month of chemotherapy (T3), and at the 12(th) month of chemotherapy (T4). Dietary AGE intake was represented by carboxymethyl lysine (dCML). Serum levels of CML, inflammation, and oxidation biomarkers were determined with biochemical blood tests. The results were compared according to human epidermal growth factor receptor-2 (HER2) status.ResultsThirty-two women with BC and 32 age and body mass index-matched healthy women participated. No significant correlation was found between dCML and serum CML, inflammatory or oxidative stress biomarkers at T1, T2, and T4. A weak positive correlation was demonstrated between dCML and serum malondialdehyde levels (rho=0.355, p=0.046) at T3. The serum CML, inflammation, and oxidation biomarker levels of the HER2- group were significantly higher than those of the HER2+ group at T1.ConclusionThis study suggests that there is limited correlation between dCML and serum inflammation and oxidative stress biomarkers in BC patients. Inflammation and oxidative biomarker levels appear to decline with treatment although dietary and serum AGE levels show not a corresponding significant decline. The HER2- subtype appears to be associated with higher dietary and serum AGEs and higher inflammatory and oxidative stress biomarkers.en_US
dc.identifier.doi10.1007/s00520-023-07772-w
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue6en_US
dc.identifier.pmid37183232en_US
dc.identifier.scopus2-s2.0-85159226962en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00520-023-07772-w
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10974
dc.identifier.volume31en_US
dc.identifier.wosWOS:000988978500002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSupportive Care In Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectAdvanced Glycation End Productsen_US
dc.subjectInflammationen_US
dc.subjectOxidationen_US
dc.titleAre dietary and serum advanced glycation end-products related to inflammation and oxidation biomarkers in breast cancer patients: a follow-up studyen_US
dc.typeArticleen_US

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