INFLUENCE OF GLYCEMIC CONTROL AND BODY COMPOSITION ON IRISIN LEVELS IN CHILDREN WITH TYPE 1 DIABETES MELLITUS

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dc.contributor.authorBeray, S. E.
dc.contributor.authorAtabek, M. E.
dc.contributor.authorKucukkagnici, Y.
dc.contributor.authorKurban, S.
dc.contributor.authorSelver, M. B.
dc.contributor.authorIyisoy, M. S.
dc.date.accessioned2024-02-23T14:38:02Z
dc.date.available2024-02-23T14:38:02Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAim. We investigated the relationship between irisin concentrations and glycemic control, body composition and anthropometric measures in children with type 1 diabetes mellitus. Methods. The study involved 40 subjects with T1DM prospectively. Glycemic control was evaluated. Body composition was analyzed with a bioimpedance analyzer (BIA). Serum irisin concentrations were measured using an ELISA kit. Results. Irisin levels were found higher in BMI <17 kg/m(2) group (p=0.002) compared to BMI >17 kg/m(2). Irisin level was negatively correlated with weight, height, BMI, fat free mass, skeletelal muscle mass, basal metabolic rate (r= -0.40, p= 0.011; r=-0.32, p=0.046; r=-0.366, p= 0.022; r=-0.423, p= 0.007; r=-0.430, p=0.006; r=-0.416, p=0.009, respectively); there was a strong correlation between LDL-C and irisin levels (r=0.367, p=0.02). In multivariate linear regression analyses model, irisin concentrations were correlated with weight (beta-coefficient= - 0.391, p= 0.015). LDL-C is associated, but not correlated significantly with irisin levels, (beta-coefficient =0.272, p=0.084). Conclusion. As a result, weight and LDL-C were the predictors of circulating irisin. To our knowledge, this study is the first examining association between irisin levels and body composition comprehensively, in children with type 1 diabetes mellitus.en_US
dc.identifier.doi10.4183/aeb.2022.24
dc.identifier.endpage28en_US
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue1en_US
dc.identifier.pmid35975256en_US
dc.identifier.scopus2-s2.0-85135593891en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2022.24
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16337
dc.identifier.volume18en_US
dc.identifier.wosWOS:000850761500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofActa Endocrinologica-Bucharesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIrisinen_US
dc.subjectType 1 Diabetes Mellitusen_US
dc.subjectChildrenen_US
dc.titleINFLUENCE OF GLYCEMIC CONTROL AND BODY COMPOSITION ON IRISIN LEVELS IN CHILDREN WITH TYPE 1 DIABETES MELLITUSen_US
dc.typeArticleen_US

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