The Effect of Oxidative Stress Which Can Be Demonstrated with Thiol/Disulfide Homeostasis in Varicocele Patients on Sperm Parameters

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dc.contributor.authorSonmez, Mehmet G.
dc.contributor.authorKozanhan, Betul
dc.contributor.authorDeniz, Cigdem D.
dc.contributor.authorIyisoy, Mehmet S.
dc.contributor.authorKilinc, Muzaffer T.
dc.contributor.authorEcer, Gokhan
dc.contributor.authorSonmez, Leyla Ozturk
dc.date.accessioned2024-02-23T14:44:56Z
dc.date.available2024-02-23T14:44:56Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractBackground: We planned to evaluate the effects of thiol/disulfide homeostasis (TDH) on sperm parameters in varicocele patients in this study. Methods: According to sperm concentration (< 15 x 10(6)/mL) sperm morphology (<4%) and progressive motility values (<32%) in the semen analysis, patients were divided into four groups as oligozoospermia (OS, n = 27), oligoasthenozoospermia (OAS, n = 20), oligoteratozoospermia (OTS, n = 26), and oligoasthenoteratozoospermia (OATS, n = 19). Patients with varicocele diagnosis but no pathology in semen analysis were accepted as the control group (n = 25). Groups with impaired semen analysis results were compared to the control group. Results: No difference was detected between OS, OAS, OTS, and OATS groups and the control group in demographical (age, BMI) and varicocele parameters (vein diameter, grade). A significant difference was observed in disulfide level, disulfide/native thiol, disulfide/total thiol rates among OS, OAS, OTS, OATS groups and the control group in the evaluation of TDH parameters. They were significantly higher in OATS group. In OS, OAS, OTS, and OATS groups, it was found that native thiol and total thiol levels were lower and disulfide level was higher than control group, and thiol/disulfide homeostasis shifted to the disulfide side. It was detected that when disulfide value increases 1 mu mol/L, the morphology deteriorated 0.3% and sperm concentration (10(6)/mL) decreased 0.74 and progressive motility decreased 0.68%. Conclusions: The results of the present study suggest that patients with varicocele who have impaired sperm parameters have oxidative stress characterized by TDH slide towards disulfide side and inadequate antioxidant response identified by a lower level of native thiol compared to controls.en_US
dc.identifier.doi10.7754/Clin.Lab.2018.180306
dc.identifier.endpage1828en_US
dc.identifier.issn1433-6510
dc.identifier.issue11.Araen_US
dc.identifier.pmid30549975en_US
dc.identifier.scopus2-s2.0-85058606256en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1823en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2018.180306
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17151
dc.identifier.volume64en_US
dc.identifier.wosWOS:000452882500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Oxidant Statusen_US
dc.subjectOxidative Stressen_US
dc.subjectSperm Parametersen_US
dc.subjectThiol/Disulfide Homeostasisen_US
dc.subjectVaricoceleen_US
dc.titleThe Effect of Oxidative Stress Which Can Be Demonstrated with Thiol/Disulfide Homeostasis in Varicocele Patients on Sperm Parametersen_US
dc.typeArticleen_US

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