Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients

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dc.contributor.authorTezcan, Dilek
dc.contributor.authorSivrikaya, Abdullah
dc.contributor.authorErgun, Dilek
dc.contributor.authorOzer, Halil
dc.contributor.authorEryavuz Onmaz, Duygu
dc.contributor.authorKorez, Muslu Kazim
dc.contributor.authorAkdag, Turan
dc.date.accessioned2024-02-23T13:55:56Z
dc.date.available2024-02-23T13:55:56Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: Interstitial lung disease (ILD) is one of the most severe complications which is associated with connective tissue disease (CTD) and causes to morbidity and mortality. So, we aimed to determine serum levels of interleukin-6 (IL-6), IL-13, and IL-17, to investigate whether these cytokines are related to CTD-ILD, and to find their possible contribution to determining the prognosis of the disease. Methods: A total of 150 participants, 80 patients diagnosed with CTD-ILD (mean age, 58.21 +/- 12.36) and 70 healthy controls (mean age, 57.07 +/- 9.60) were recruited from the rheumatology department between January 2016 and June 2019 in the study. High-resolution computed tomography (HRCT) findings were scored as similarly to previous studies. Serum IL-6, IL 13, and IL-17 levels were measured by ELISA test kits. Results: The levels of IL-6, IL-13, and IL-17 in CTD patients were significantly higher than the healthy individuals (p < 001), but the HRCT score's relation were not determined. IL-6 was associated with disease duration and disease activity scores of DAS28, ESDAII, and dSSc. There was a significant relation between dSSc, HCRT fibrosis, and total score. CRP, hemoglobin, and platelets were associated with the HRCT inflammation pattern. Conclusion: At the study, it has been observed that serum IL-13, IL-6 and IL-17 levels are increased in patients with CTD-ILD. Besides, IL-6 was associated with disease activity scores of DAS28, ESDAII, and dSSc. Also, HRCT fibrosis score is associated with dSSc. Further and comprehensive studies are needed to understand better the complex intersection of lung disease with systemic autoimmunity.en_US
dc.description.sponsorshipSelcuk University Faculty of Medicine Hospital [:20401029]en_US
dc.description.sponsorshipThis study funded by Selcuk University Faculty of Medicine Hospital (Proje No:20401029).en_US
dc.identifier.doi10.1007/s10067-021-05773-w
dc.identifier.endpage4724en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue11en_US
dc.identifier.pmid34181129en_US
dc.identifier.scopus2-s2.0-85117207081en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4713en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-021-05773-w
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11028
dc.identifier.volume40en_US
dc.identifier.wosWOS:000667601200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConnective Tissue Diseaseen_US
dc.subjectInterstitial Lung Diseasesen_US
dc.subjectInterleukin-6en_US
dc.subjectInterleukin-13en_US
dc.subjectInterleukin-17en_US
dc.titleEvaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patientsen_US
dc.typeArticleen_US

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