Sleep quality, morningness-eveningness preference, mood profile, and levels of serum melatonin in migraine patients: a case-control study

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dc.contributor.authorKozak, Hasan Huseyin
dc.contributor.authorBoysan, Murat
dc.contributor.authorUca, Ali Ulvi
dc.contributor.authorAydin, Adem
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorGenc, Emine
dc.contributor.authorAltas, Mustafa
dc.date.accessioned2024-02-23T14:00:09Z
dc.date.available2024-02-23T14:00:09Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractThe melatonin as the pineal gland's secretory product is implicated in the pathophysiology of migraine. Melatonin has critical functions in human physiology, and research underscores the importance of melatonin in circadian rhythm, sleep, and mood regulation. Clinical observations have indicated that migraine attacks have a seasonal, menstrual, and circadian timing, suggesting that chronobiological mechanisms and their alterations may causally involve in the etiology of the disease. However, the topic has received relatively little attention in the migraine literature. Associations between melatonin, circadian preference, sleep, and mood states were investigated in the current study. Fifty-five patients (47 females and 8 males) were compared to 57 gender and age-matched control subjects (40 females and 17 males). A socio-demographical questionnaire, the Beck Depression Inventory, Beck Anxiety Inventory (BAI), Pittsburgh Sleep Quality Index (PSQI), Profile of Mood States (POMS), and Morningness-Eveningness Questionnaire were administered to volunteers. Blood samples were taken from all participants at about 1:00 AM in an unlit room not to hamper melatonin secretion, and blood melatonin levels were measured using quantitative ELISA test. In comparison with controls, melatonin levels were significantly lower among migraine patients. Migraineurs reported significantly greater scores on the BAI, confusion-bewilderment subscale of the POMS, and total and sleep latency subscale of the PSQI. Migraine patients who had nausea during the migraine attacks and who reported bouts relevant to certain food consumption, such as cheese or chocolate, had significantly lower levels of melatonin. Contrarily, groups did not reveal statistically substantial difference in circadian preferences.en_US
dc.description.sponsorshipNecmettin Erbakan University Research Projects Fund [151218005]en_US
dc.description.sponsorshipThis research was granted by Necmettin Erbakan University Research Projects Fund (Grant Number: 151218005).en_US
dc.identifier.doi10.1007/s13760-016-0723-1
dc.identifier.endpage119en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue1en_US
dc.identifier.pmid27858294en_US
dc.identifier.scopus2-s2.0-84995773201en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-016-0723-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11462
dc.identifier.volume117en_US
dc.identifier.wosWOS:000394999100014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSleepen_US
dc.subjectCircadian Rhythmen_US
dc.subjectMood Statesen_US
dc.subjectAnxietyen_US
dc.subjectMelatonin Hormoneen_US
dc.titleSleep quality, morningness-eveningness preference, mood profile, and levels of serum melatonin in migraine patients: a case-control studyen_US
dc.typeArticleen_US

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