The relationship of the apolipoprotein E gene polymorphism in Turkish Type 2 Diabetic Patients with and without diabetic foot ulcers

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dc.contributor.authorMehmet, Erdogan
dc.contributor.authorZuhal, Eroglu
dc.contributor.authorMustafa, Kulaksizoglu
dc.contributor.authorSoner, Solmaz
dc.contributor.authorAsli, Tetik
dc.contributor.authorSevki, Cetinkalp
dc.date.accessioned2024-02-23T14:02:42Z
dc.date.available2024-02-23T14:02:42Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractAims: The aim of this study was to investigate the association between Apolipoprotein E (ApoE) gene polymorphism in the development of diabetic foot ulcers in Type 2 diabetes Turkish patients. Materials and methods: The ApoE genotypes were determined retrospectively in 50 patients with diabetic foot and 50 without diabetic foot and a control group of 50 healthy individuals. Results: The genotype ApoE distribution did differ between the control group (E2E3 44%, E3E3 38%, E3E4 18%) and Type 2 Diabetic Patients (E2E3 6%, E3E3 81%, E3E4 16%) (p < 0.001). The genotype ApoE distribution did not differ between Type 2 Diabetic Patients group (E2E3 4%, E3E3 86%, E3E4 4%) and diabetic foot ulcers (E2E3 8%, E3E3 76%, E3E4 16%) (p > 0.05). The frequency of the E2,E3,E4 allele in between the control group and Type 2 Diabetic Patients were no similar for the groups (E2 22%, E3 69%, E4 9% and E2 3%, E3 90.5%, E4 6.5%, respectively) (p < 0.001). The frequency of the E2-E4 allele in between the Type 2 Diabetic Patients and diabetic foot ulcers were similar for the groups (E2 2%, E3 93%, E4 5% and E2 4%, E3 88%, E4 8%, respectively) (p > 0.05). Conclusions: The gene polymorphism of ApoE and E3 allele are a risk factor for diabetes, but gene polymorphism of ApoE is not an independent risk factor for diabetic foot. Lack of association between ApoE gene polymorphism and Type 2 diabetic foot ulcers might be due to ethnic differences. (C) 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.dsx.2015.09.006
dc.identifier.endpageS33en_US
dc.identifier.issn1871-4021
dc.identifier.issn1878-0334
dc.identifier.issue1en_US
dc.identifier.pmid26476487en_US
dc.identifier.scopus2-s2.0-84951841622en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageS30en_US
dc.identifier.urihttps://doi.org/10.1016/j.dsx.2015.09.006
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11820
dc.identifier.volume10en_US
dc.identifier.wosWOS:000832032300006en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofDiabetes & Metabolic Syndrome-Clinical Research & Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoe Gene Polymorphismen_US
dc.subjectDiabetic Foot Ulcersen_US
dc.subjectTurkish Populationen_US
dc.titleThe relationship of the apolipoprotein E gene polymorphism in Turkish Type 2 Diabetic Patients with and without diabetic foot ulcersen_US
dc.typeArticleen_US

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