Serum Brain-Derived Neurotrophic Factor, Glial-Derived Neurotrophic Factor, Nerve Growth Factor and Neurotrophin-3 Levels in Preschool Children with Language Disorder

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorFerahkaya, Hursit
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorEnergin, Meryem Vesile
dc.date.accessioned2024-02-23T14:34:26Z
dc.date.available2024-02-23T14:34:26Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Accumulating studies demonstrate that neurotrophins may play a crucial role in a variety of neurodevelopmental disorders. However, little data are available regarding the potential role of neurotrophins in language disorder (LD). This study aimed to investigate serum brain-derived neurotrophic factor (BDNF), glialderived neurotrophic factor (GDNF), nerve growth factor (NGF) and neurotrophin-3 (NTF3) levels in preschool children with LD. Methods: A total of 43 cases with LD and 43 healthy controls aged 18 to 60 months were enrolled in the study. The development levels and psychiatric symptoms of the children were determined by the Ankara Developmental Screening Inventory and Child Behavior Checklist 1.5-5, respectively. Serum neurotrophin levels were assessed by enzyme-linked immunosorbent assay kits. Results: Serum GDNF and NGF levels were significantly higher, serum BDNF and NTF3 levels were significantly lower in the LD group than in the control group. However, with logistic regression analyses, only negative relationship of BDNF and NTF3 levels with the presence of LD remained significant after accounting for the confounders including development level and coexisting psychiatric symptoms. Conclusions: These results suggest that low BDNF and NTF3 levels have independent negative relationships with LD, which could be contribute to etiopathogenesis of the disorder.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [119S839]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Scientific and Technological Research Council of Turkey (TUBITAK) (Project no: 119S839).en_US
dc.identifier.doi10.29399/npa.27274
dc.identifier.endpage132en_US
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue2en_US
dc.identifier.pmid34188595en_US
dc.identifier.scopus2-s2.0-85109725816en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://doi.org/10.29399/npa.27274
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15615
dc.identifier.volume58en_US
dc.identifier.wosWOS:000662245500010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegien_US
dc.relation.ispartofNoropsikiyatri Arsivi-Archives Of Neuropsychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLanguage Disorderen_US
dc.subjectPreschool Childrenen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectGlial-Derived Neurotrophic Factoren_US
dc.subjectNerve Growth Factoren_US
dc.subjectNeurotrophin-3en_US
dc.titleSerum Brain-Derived Neurotrophic Factor, Glial-Derived Neurotrophic Factor, Nerve Growth Factor and Neurotrophin-3 Levels in Preschool Children with Language Disorderen_US
dc.typeArticleen_US

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