Isotretinoin's action against cisplatin-induced ototoxicity in rats

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dc.contributor.authorAlan, Mehmet Akif
dc.contributor.authorEryilmaz, Mehmet Akif
dc.contributor.authorKaymaz, Figen
dc.contributor.authorSuzer, Aysegul
dc.contributor.authorAricigil, Mitat
dc.date.accessioned2024-02-23T14:49:08Z
dc.date.available2024-02-23T14:49:08Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractCurrent data do not support the routine use of any agent to prevent cisplatin ototoxicity. Although there are various diseases in which derivatives of vitamin A are used due to their antioxidant effects, there is no study for prevention from ototoxicity. In this study, the protective effect of isotretinoin was investigated on cisplatin ototoxicity in rats. 21 Wistar Albino rats were divided randomly into 3 groups. Group I: cisplatin, Group II: cisplatin + isotretinoin and Group III was the control group. Hearing assessment of all rats was done with ABR and DPOAE tests before and after the procedure. After the procedure, cochleas were resected and transmission electron microscopic examination was performed. Our DPOAE and ABR findings showed that isotretinoin has protective effects on cisplatin ototoxicity. According to transmission electron microscopic findings, isotretinoin has protective effects on cell integrity. We think that new experimental and clinical studies to be carried out in this regard may give us a new option on prevention of cochlea from ototoxicity.en_US
dc.identifier.endpage2584en_US
dc.identifier.issn1011-601X
dc.identifier.issue6en_US
dc.identifier.pmid30587464en_US
dc.identifier.scopus2-s2.0-85059243207en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2579en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18019
dc.identifier.volume31en_US
dc.identifier.wosWOS:000454379100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Karachien_US
dc.relation.ispartofPakistan Journal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIsotretinoinen_US
dc.subjectCarotenoidsen_US
dc.subjectCisplatinen_US
dc.subjectOtotoxicityen_US
dc.titleIsotretinoin's action against cisplatin-induced ototoxicity in ratsen_US
dc.typeArticleen_US

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