Morphometric analysis of hippocampus and intracranial formations based on their stages in patients diagnosed with major cognitive disorder

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dc.contributor.authorYucel, Nurullah
dc.contributor.authorSeker, Muzaffer
dc.contributor.authorYilmaz, Mehmet Tugrul
dc.contributor.authorSakci, Zakir
dc.contributor.authorBukte, Yasar
dc.date.accessioned2024-02-23T14:41:44Z
dc.date.available2024-02-23T14:41:44Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground: Alzheimer???s disease (AD) is a major cognitive disorder classified as a common type of dementia. Magnetic resonance imaging (MRI) is the most practical method for diagnostic purposes in AD. The aim of the study was to determine the volume of the hippocampus and intracranial structures in AD using MRI. Methods: A total of 102 patients with AD were classified based on the mini mental test scores as early, moderate, and advanced stage. The control group included 35 healthy subjects. MRI were compared between the patients and control groups based on the calculations made utilizing volBrain software. Intracranial volumetric parameters were also compared between the three stages of AD. Results: The white matter volumes, total hippocampus, total cerebrum, right cerebrum, left cerebrum, truncus encephalic, total nucleus caudatus and total corpus amygdaloideum were significantly increased in the AD. The white matter volumes, right hippocampus, left hippocampus, total cerebrum, left cerebrum, and right cerebellum were significantly increased in the patients in the early stage compared to the patients in the advanced stage AD. Conclusion: The most efficient volumetric study in AD could be performed by obtaining long-term periodic morphometric data of an early diagnosed and regularly followed-up patient population.en_US
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.description.sponsorshipThis study was supported by the Turkish Academy of Sciences.en_US
dc.identifier.doi10.55730/1300-0144.5353
dc.identifier.endpage624en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid36326329en_US
dc.identifier.scopus2-s2.0-85133165430en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage613en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5353
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16972
dc.identifier.volume52en_US
dc.identifier.wosWOS:000816957200011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer?S Diseaseen_US
dc.subjectDementiaen_US
dc.subjectHippocampusen_US
dc.subjectWhite Matteren_US
dc.subjectVolumetric Analysisen_US
dc.titleMorphometric analysis of hippocampus and intracranial formations based on their stages in patients diagnosed with major cognitive disorderen_US
dc.typeArticleen_US

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