Acrylamide-treatment and responses to phenylephrine and potassium in rat aorta

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dc.contributor.authorNurullahoglu-Atalik, E.
dc.contributor.authorOkudan, N.
dc.contributor.authorBelviranli, M.
dc.contributor.authorEsen, H.
dc.contributor.authorYener, Y.
dc.contributor.authorOznurlu, Y.
dc.date.accessioned2024-02-23T14:32:06Z
dc.date.available2024-02-23T14:32:06Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractAcrylamide (ACR) is a chemical used in many industries around the world and was found to form naturally in foods cooked at high temperatures. The aim of the present study is to evaluate the influence of ACR treatment on vascular responses to phenylephrine (PHE; 10(-9)-3x10(-4) M) and potassium chloride (KCl; 5-100 mM). We also examined the role of gender in these responses. The animals in both genders were divided into three groups as follows. (1) Control animals, (2) ACR-I; ACR-treated (2 mg/kg-d for 90 days), (3) ACR-II; ACR-treated (5 mg/kg-d for 90 days). Male rat aortas were more sensitive to PHE and KCl than female aortas. ACR-treatment increased the sensitivity to PHE and KCl, in both genders. Compared to the control group, ACR treatment significantly reduced the luminal area of both male and female rat aortas. Furthermore, the responses to PHE and KCl were similar in both 2 mg/kg-d ACR-treated rat aortas with 5 mg/kg-d ACR-treated rat aortas, in both genders. The results of this study suggest that ACR treatment affects vascular contractility and morphology in both gender of rat aorta.en_US
dc.identifier.doi10.1556/APhysiol.99.2012.4.6
dc.identifier.endpage429en_US
dc.identifier.issn0231-424X
dc.identifier.issn1588-2683
dc.identifier.issue4en_US
dc.identifier.pmid23238544en_US
dc.identifier.scopus2-s2.0-84871301082en_US
dc.identifier.startpage420en_US
dc.identifier.urihttps://doi.org/10.1556/APhysiol.99.2012.4.6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15488
dc.identifier.volume99en_US
dc.identifier.wosWOS:000312262700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rten_US
dc.relation.ispartofActa Physiologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectAortaen_US
dc.subjectContractionsen_US
dc.subjectGenderen_US
dc.subjectKclen_US
dc.subjectPhenylephrineen_US
dc.titleAcrylamide-treatment and responses to phenylephrine and potassium in rat aortaen_US
dc.typeArticleen_US

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