Is oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma?

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dc.contributor.authorSonmez, Mehmet G.
dc.contributor.authorKozanhan, Betul
dc.contributor.authorDeniz, Cigdem D.
dc.contributor.authorGoger, Yunus E.
dc.contributor.authorKilinc, Muzaffer T.
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorEre, Ozcan
dc.date.accessioned2024-02-23T14:40:55Z
dc.date.available2024-02-23T14:40:55Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractAim of the study: We aim to examine the relation between thiol/disulphide homeostasis and transrectal ultrasound guided prostate biopsy (TRUS-Bx) results and evaluate whether it was effective on the distinction of benign and malign prostate disease. Material and methods: The study included 29 men histopathologically diagnosed as prostate adenocancer (Pca) (group 1), 30 men having benign prostate hyperplasia (BPH) (group 2) and age match 30 healthy individuals in the control group (group 3). Thiol/disulphide homeostasis was measured using a novel automatic and spectrophotometric method. Results: Among the three groups, a statistically significant difference was detected among native thiol, total thiol levels and disulphide/total thiol, disulphide/native thiol and native thiol/total thiol ratios which are thiol/disulphide homeostasis parameters apart from disulphide (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001 respectively). Additionally, no significant difference was detected in albumin and total protein levels among the groups (p = 0.223, p = 0.316 respectively). Serum native and total thiol levels were high and disulphide level was low in group 1 when compared to the group 2 (p = 0.003, p = 0.007, p = 0.265 respectively). In addition, serum native thiol, total thiol and disulphide levels were low in group 1 when compared to the group 3, but while low native and total thiol levels were significant, low disulphide levels were not found significant (p < 0.001, p < 0.001, p = 0.331, respectively). Conclusions: Thiol/disulphide homeostasis was found to be disturbed in Pca patients detected with TRUS-Bx. This is suggesting serum native thiol, total thiol level and ratios provides a novel biomarker for the role for oxidative stress in disease etiopathogenesis.en_US
dc.identifier.doi10.5114/ceji.2017.72285
dc.identifier.endpage179en_US
dc.identifier.issn1426-3912
dc.identifier.issn1644-4124
dc.identifier.issue2en_US
dc.identifier.pmid30135630en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage174en_US
dc.identifier.urihttps://doi.org/10.5114/ceji.2017.72285
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16641
dc.identifier.volume43en_US
dc.identifier.wosWOS:000440837800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofCentral European Journal Of Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDynamic Thiol-Disulphide Homeostasisen_US
dc.subjectProstate Canceren_US
dc.subjectBenign Prostatic Hyperplasiaen_US
dc.subjectOxidative Stressen_US
dc.titleIs oxidative stress measured by thiol/disulphide homeostasis status associated with prostate adenocarcinoma?en_US
dc.typeArticleen_US

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