Preventive Effects of Intraperitoneal Selenium on Cerebral Vasospasm In Experimental Subarachnoid Hemorrhage

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dc.contributor.authorKocaogullar, Yalcin
dc.contributor.authorIlik, Kemal
dc.contributor.authorEsen, Hasan
dc.contributor.authorKoc, Osman
dc.contributor.authorGuney, Onder
dc.date.accessioned2024-02-23T14:21:04Z
dc.date.available2024-02-23T14:21:04Z
dc.date.issued2010
dc.departmentNEÜen_US
dc.description.abstractVasospasm is an important cause of morbidity and mortality with subarachnoid hemorrhage (SAH). The effect of intraperitoneal administration of selenium, which is an antioxidant on cerebral vasospasm was investigated in an experimental model. By means of intracisternal blood injection model, SAH was induced in 24 rabbits, which were randomly divided into 3 groups (group I = control group, group 2 = SAH alone group, and group 3 = SAH plus selenium group). Basilar artery angiography was performed on day 0 and day 3 as described. Intraperitoneal selenium (0.05 mg/kg) treatment was started after the induction of SAH and administered once a day. Three days later, the animals were killed and the basilar artery was examined histologically for the luminal diameter and thickness of the arterial muscular wall. The mean values for the measurements of angiographic luminal diameter, pathologic luminal area.. Muscular wall thickness derived from the blind observer were analyzed statistically. There was no statistically significant difference in basal angiographic luminal diameter evaluation between groups 1-2-3 (P > 0.005). But in third day angiography; comparison of Group 2 and group 1-3 showed statistically significant differences (P < 0.001). In pathologic investigation; there was statistically significant difference in luminal area and muscular wall thickness of the basilar artery between groups 1, 2, and 3 (P < 0.005). Intraperitoneal selenium treatment was found effective by increasing the angiographic diameter, pathologic luminal area and reducine muscular wall thickness measurements. This is the first study to show that intraperitoneal administration of selenium is effective in preventing vasospasm after SAH in rabbits.en_US
dc.identifier.doi10.1097/ANA.0b013e3181b26a63
dc.identifier.endpage58en_US
dc.identifier.issn0898-4921
dc.identifier.issn1537-1921
dc.identifier.issue1en_US
dc.identifier.pmid19779374en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1097/ANA.0b013e3181b26a63
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13437
dc.identifier.volume22en_US
dc.identifier.wosWOS:000273316200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Neurosurgical Anesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.subjectCerebral Vasospasmen_US
dc.subjectSeleniumen_US
dc.subjectRabbiten_US
dc.titlePreventive Effects of Intraperitoneal Selenium on Cerebral Vasospasm In Experimental Subarachnoid Hemorrhageen_US
dc.typeArticleen_US

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