Effects of urine alkalinization with sodium bicarbonate orally on lower urinary tract symptoms in female patients: a pilot study

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dc.contributor.authorSonmez, Mehmet Giray
dc.contributor.authorGoger, Yunus Emre
dc.contributor.authorEcer, Gokhan
dc.contributor.authorAtici, Ahmet
dc.contributor.authorOzkent, Mehmet Serkan
dc.contributor.authorOzturk, Ahmet
dc.date.accessioned2024-02-23T13:43:31Z
dc.date.available2024-02-23T13:43:31Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractIn this study, we planned to explore the effects of sodium bicarbonate orally (NaHCO3) treatment on female patients with lower urinary tract symptoms (LUTS) who have acidic urine pH values (< 6). NaHCO3 was given orally to 33 female patients for 4 weeks at a dose of 2 x 4 g/day. Laboratory values, bladder diary, the Patient Perception of Bladder Condition Score (PPBC), Patient Perception of Intensity of Urgency Scale (PPIUS), Overactive Bladder-Validated 8-question Awareness tool (OAB-V8), Pelvic Pain and Urgency & Frequency Patient Symptom Scale tests (PUFSS), and the King's Health Questionnaire (KHQ) scores before and after treatment were compared. A significant increase was detected in urine pH values measured after treatment (5.31 +/- 0.52 to 7.2 +/- 0.66, p < 0.001), but not in blood pH values (7.369 +/- 0.33 to 7.384 +/- 0.28, p = 0.14). After treatment, a significant decrease was detected in daily frequency, nocturia, urgency, and urge incontinence prevalence (p < 0.001,p = 0.003, p < 0.001, p = 0.002, respectively) and PPBC, PPIUS, PUFSS, and OAB-V8 symptom scores (p = 0.004, p = 0.002, p < 0.001, p < 0.001, respectively). A significant decrease was detected in all KHQ subunit scores. Urine alkalinization with NaHCO3 orally in female patients with LUTS and acidic urine pH has a significant level of positive effects on symptoms and symptom scores. Our results show that this new treatment modality-which is inexpensive, easy to use, and has a low side-effect profile is effective in this chronic patient group.en_US
dc.identifier.doi10.1007/s00192-017-3492-3
dc.identifier.endpage1033en_US
dc.identifier.issn0937-3462
dc.identifier.issn1433-3023
dc.identifier.issue7en_US
dc.identifier.pmid28975365en_US
dc.identifier.scopus2-s2.0-85030328664en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1029en_US
dc.identifier.urihttps://doi.org/10.1007/s00192-017-3492-3
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10841
dc.identifier.volume29en_US
dc.identifier.wosWOS:000435584200015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofInternational Urogynecology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrine Alkalinizationen_US
dc.subjectSodium Bicarbonate Orallyen_US
dc.subjectLower Urinary Tract Symptomsen_US
dc.subjectUrine Phen_US
dc.titleEffects of urine alkalinization with sodium bicarbonate orally on lower urinary tract symptoms in female patients: a pilot studyen_US
dc.typeArticleen_US

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