Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study

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dc.contributor.authorMercan, Aysel
dc.contributor.authorUzun, Sema Tuncer
dc.contributor.authorKeles, Sevgi
dc.contributor.authorHacibeyoglu, Gulcin
dc.contributor.authorYilmaz, Resul
dc.contributor.authorReisli, Ruhiye
dc.date.accessioned2024-02-23T14:34:52Z
dc.date.available2024-02-23T14:34:52Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: Although neuropathic pain is a severe and common pain, its pathophysiology has not been elucidated yet. Studies in recent years have focused on the immune system's role in the pathogenesis of neuropathic pain. The aim of this study was to investigate the role of immunological mechanisms in neuropathic pain and the effect of pregabalin by measuring immunological marker levels in peripheral blood before and after pregabalin treatment in postherpetic neuralgia (PHN) patients with neuropathic pain. Methods: Forty patients diagnosed with PHN were included in the study. CD4, T follicular cells (If h: CD4(+)CXCR5(+)PD1(+)), Th17 (CD4(+)CCR6(+) and CD4(+)IL17A(+)), regulatory T cells (Treg: CD4(+)CD25(+)foxp3(+)), Th1 (CD4(+) CXCR3(+) and CD4(+ )IFN-gamma(+)) and Th2 (CD4(+) IL-4(+)) cell ratios were measured in peripheral blood samples before treatment and after 3 months of treatment. Results: When immunological marker and inflammation parameter levels were compared before and after treatment, the helper T cell ratio (CD3(+), CD4(+)) was 30.28 +/- 12.27% before treatment and 34.93 +/- 11.70% after treatment, so there was a statistically significant increase (P = 0.028). Th17 was 4.75 +/- 5.02% before treatment and 5.80 +/- 3.13% after treatment, and there was a statistically significant increase (P = 0.036). Conclusions: Immunological mechanisms play an essential role in the pathogenesis of neuropathic pain, immunologically based treatment approach will be the critical point of treatment.en_US
dc.description.sponsorshipScientific Research Projects Coordinator of Necmettin Erbakan University [181518025]en_US
dc.description.sponsorshipThe study was financed by the Scientific Research Projects Coordinator of Necmettin Erbakan University (project number: 181518025) .en_US
dc.identifier.doi10.3344/kjp.2021.34.4.463
dc.identifier.endpage470en_US
dc.identifier.issn2005-9159
dc.identifier.issn2093-0569
dc.identifier.issue4en_US
dc.identifier.pmid34593664en_US
dc.identifier.scopus2-s2.0-85117903770en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage463en_US
dc.identifier.urihttps://doi.org/10.3344/kjp.2021.34.4.463
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15784
dc.identifier.volume34en_US
dc.identifier.wosWOS:000713914600010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Pain Socen_US
dc.relation.ispartofKorean Journal Of Painen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytokinesen_US
dc.subjectImmune Systemen_US
dc.subjectInterleukin-17en_US
dc.subjectNeuralgiaen_US
dc.subjectPostherpeticen_US
dc.subjectPainen_US
dc.subjectPregabalinen_US
dc.subjectTh17 Cellsen_US
dc.subjectT-Lymphocytesen_US
dc.subjectRegulatoryen_US
dc.titleImmunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational studyen_US
dc.typeArticleen_US

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