Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorToker, Aysun
dc.contributor.authorIsik, Umit
dc.contributor.authorKilinc, Ibrahim
dc.date.accessioned2024-02-23T13:55:53Z
dc.date.available2024-02-23T13:55:53Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractIt has been suggested that neurotrophins are involved in the etiopathogenesis of attention-deficit/hyperactivity disorder (ADHD). This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neurotrophin-3 (NTF3) levels between children with ADHD and healthy controls. A total of 110 treatment-naive children with the combined presentation of ADHD and 44 healthy controls aged 8-18 years were enrolled in this study. The severity of ADHD symptoms was determined by scores on the Conners' Parent Rating Scale-Revised Short and Conners' Teacher Rating Scale-Revised Short. The severity of depression and anxiety symptoms of the children were evaluated by the self-report inventories. Serum levels of neurotrophins were measured using commercial enzyme-linked immunosorbent assay kits. The multivariate analysis of covariance (MANCOVA) revealed a significant main effect of groups in the levels of serum neurotrophins, an effect that was independent of age, sex, and the severity of the depression and anxiety. The analysis of covariance (ANCOVA) indicated that the mean serum GDNF and NTF3 levels of ADHD patients were significantly higher than that of controls. However, serum BDNF and NGF levels did not show any significant differences between groups. No correlations between the levels of serum neurotrophins and the severity of ADHD were observed. These results suggest that elevated serum GDNF and NTF3 levels may be related to ADHD in children.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [151218004]en_US
dc.description.sponsorshipWe thank the patients and their family members who participated in this study. Funding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Necmettin Erbakan University (Project No: 151218004).en_US
dc.identifier.doi10.1007/s00787-016-0898-2
dc.identifier.endpage363en_US
dc.identifier.issn1018-8827
dc.identifier.issn1435-165X
dc.identifier.issue3en_US
dc.identifier.pmid27561780en_US
dc.identifier.scopus2-s2.0-84983455336en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage355en_US
dc.identifier.urihttps://doi.org/10.1007/s00787-016-0898-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11005
dc.identifier.volume26en_US
dc.identifier.wosWOS:000395000600010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Child & Adolescent Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAttention-Deficit/Hyperactivity Disorderen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectGlial-Derived Neurotrophic Factoren_US
dc.subjectNerve Growth Factoren_US
dc.subjectNeurotrophin-3en_US
dc.titleSerum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorderen_US
dc.typeArticleen_US

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