Unplanned irradiation of internal mammary lymph nodes in breast cancer

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dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorAktan, Meryem
dc.contributor.authorKoc, Mehmet
dc.contributor.authorDemir, Hikmettin
dc.contributor.authorDemir, Lutfi Saltuk
dc.date.accessioned2024-02-23T13:59:35Z
dc.date.available2024-02-23T13:59:35Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractTo evaluate the incidental dose to the internal mammary chain (IMC) in patients treated with three-dimensional conformal radiotherapy, to estimate the predictors affecting the magnitude of IMC receiving dose and to determine the predictive role of clinical parameters on survival. Between 2009 and 2015, 348 patients undergoing RT for breast cancer were retrospectively analyzed. All patients underwent our department's routine procedure for breast cancer. The internal mammary lymph nodes were contoured according to Radiation Therapy Oncology Group (RTOG) concensus. Based on each patient's dose-volume histograms, the mean doses (D (mean)) to internal mammary gland were analyzed. Overall survival and disease-free survival were also evaluated. The median follow-up time was 38 (range 3-80) months. The D (mean) to IMC was 32.8 Gy and the dose delivered to IMC showed a greater coverage in modified radical mastectomy (MRM) group compared with breast conserving surgery (34.6 vs 26.7 Gy). The T-stage of tumor and the N-stage of tumor affected the incidental dose to IMC. The tumor size, the number of involved lymph nodes, the percentage of involved lymph nodes, hormonal status, advanced T-stage and advanced N-stage were the prognostic factors that affect survival. The IMC received meaningful incidental irradiation dose when treated with two opposite tangential fields and ipsilateral supraclavicular fossa with a single anterior field. The real effect of incidental dose on survival and the hypothesis about the benefit of incidental irradiation of IMC should be examined in clinical studies.en_US
dc.identifier.doi10.1007/s11547-017-0747-5
dc.identifier.endpage411en_US
dc.identifier.issn0033-8362
dc.identifier.issn1826-6983
dc.identifier.issue6en_US
dc.identifier.pmid28255809en_US
dc.identifier.scopus2-s2.0-85014102363en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.1007/s11547-017-0747-5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11248
dc.identifier.volume122en_US
dc.identifier.wosWOS:000401765500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofRadiologia Medicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectInternal Mammary Chainen_US
dc.subjectRadiotherapyen_US
dc.subjectDose-Volume Analysisen_US
dc.subjectSurvival Analysisen_US
dc.titleUnplanned irradiation of internal mammary lymph nodes in breast canceren_US
dc.typeArticleen_US

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