A therapeutic keypad lock decoded in drug resistant cancer cells

Basit Öğe Kaydı
dc.contributor.authorTurkoglu, Gulsen
dc.contributor.authorKoygun, Gozde Kayadibi
dc.contributor.authorZafer Yurt, Mediha Nur
dc.contributor.authorPirencioglu, Seyda Nur
dc.contributor.authorErbas-Cakmak, Sundus
dc.date.accessioned2024-02-23T14:16:47Z
dc.date.available2024-02-23T14:16:47Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractA molecular keypad lock that displays photodynamic activity when exposed to glutathione (GSH), esterase and light in the given order, is fabricated and its efficacy in drug resistant MCF7 cancer cells is investigated. The first two inputs are common drug resistant tumor markers. GSH reacts with the agent and shifts the absorption wavelength. Esterase separates the quencher from the structure, further activating the agent. After these sequential exposures, the molecular keypad lock is exposed to light and produces cytotoxic singlet oxygen. Among many possible combinations, only one 'key' can activate the agent, and initiate a photodynamic response. Paclitaxel resistant MCF7 cells are selectively killed. This work presents the first ever biological application of small molecular keypad locks.en_US
dc.description.sponsorshipEuropean Cooperation in Science and Technology (COST) [17104]; Scientific and Technological Research Council of Turkey [118Z668]en_US
dc.description.sponsorshipThis work was supported by the European Cooperation in Science and Technology (COST), action number 17104, and the Scientific and Technological Research Council of Turkey, grant number 118Z668.en_US
dc.identifier.doi10.1039/d1sc02521j
dc.identifier.endpage9758en_US
dc.identifier.issn2041-6520
dc.identifier.issn2041-6539
dc.identifier.issue28en_US
dc.identifier.pmid34349948en_US
dc.identifier.scopus2-s2.0-85111125813en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage9754en_US
dc.identifier.urihttps://doi.org/10.1039/d1sc02521j
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12796
dc.identifier.volume12en_US
dc.identifier.wosWOS:000664952500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofChemical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleA therapeutic keypad lock decoded in drug resistant cancer cellsen_US
dc.typeArticleen_US

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