The Phytochemical Profile and Biological Activity of Liquidambar orientalis Mill. var. orientalis via NF-?B and Apoptotic Pathways in Human Colorectal Cancer

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dc.contributor.authorCetinkaya, Sumeyra
dc.contributor.authorCinar Ayan, Ilknur
dc.contributor.authorSuntar, Ipek
dc.contributor.authorDursun, Hatice Gul
dc.date.accessioned2024-02-23T14:17:14Z
dc.date.available2024-02-23T14:17:14Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractLiquidambar orientalis Mill. var. orientalis (Hammamelidaceae) commonly known as oriental sweet gum is a medicinal plant endemic to Turkey, and used for treatment of wounds such as ulcers, gastritis and skin diseases. However, there are only a limited number of studies on the anticancer properties of this plant. The aim of this study is to investigate the cellular and molecular mechanisms of L. orientalis in colorectal cancer cell lines and to reveal the active therapeutic components. Antioxidant, anti-proliferative, anti-invasive and apoptotic effects were investigated for determining biological activities. The phytochemical profile and quantitation assays were carried out by using HPLC-ESI-Q-TOF-MS. The results demonstrated that leaf methanol extract (LM) of L. orientalis has the highest cytotoxic activity in HCT-116 (IC50 27.80 mu g/mL) and HT-29 (IC50 43.13 mu g/mL) cell lines as compared to the other extracts tested. Regarding chemical composition, quercetin 3-glucoside (61.005 +/- 1.527 mg/g extract), chlorogenic acid (31.627 +/- 0.970 mg/g extract), pyrogallol (9.950 +/- 0.001 mg/g extract), epigallocatechin gallate (9.671 +/- 0.004 mg/g extract), apigenin 7-O-glucoside (2.687 +/- 0.027 mg/g extract), gallic acid (2.137 +/- 0.012 mg/g extract), genistin (1.270 +/- 0.027 mg/g extract), luteolin (0.055 +/- 0.0005 mg/g extract) and kaempferol (0.506 +/- 0.007 mg/g extract) were identified as the major phytochemical compounds. Our results showed that LM extract exhibited In Vitro cytotoxic and apoptotic properties.en_US
dc.description.sponsorshipNecmettin Erbakan University, Institute of Health Sciences [161418002, 171218020]en_US
dc.description.sponsorshipThis research was supported by the Necmettin Erbakan University, Institute of Health Sciences with the two projects grant number of 161418002 and 171218020.en_US
dc.identifier.doi10.1080/01635581.2021.1952455
dc.identifier.endpage1473en_US
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue4en_US
dc.identifier.pmid34291706en_US
dc.identifier.scopus2-s2.0-85111460968en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1457en_US
dc.identifier.urihttps://doi.org/10.1080/01635581.2021.1952455
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13012
dc.identifier.volume74en_US
dc.identifier.wosWOS:000675795000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoutledge Journals, Taylor & Francis Ltden_US
dc.relation.ispartofNutrition And Cancer-An International Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleThe Phytochemical Profile and Biological Activity of Liquidambar orientalis Mill. var. orientalis via NF-?B and Apoptotic Pathways in Human Colorectal Canceren_US
dc.typeArticleen_US

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