The effect of chemotherapy on olfactory function and mucociliary clearance

Basit Öğe Kaydı
dc.contributor.authorEravci, Fakih Cihat
dc.contributor.authorUcar, Gokhan
dc.contributor.authorOzcan, Kursat Murat
dc.contributor.authorColak, Mustafa
dc.contributor.authorErgun, Yakup
dc.contributor.authorAcikgoz, Yusuf
dc.contributor.authorIkinciogullari, Aykut
dc.date.accessioned2024-02-23T13:55:50Z
dc.date.available2024-02-23T13:55:50Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjectives Olfactory sensory neurons and the olfactory mucosa are both important for optimal olfactory function. The potential nasal mucosal toxicity of chemotherapy regimens has not been assessed yet. The aim of this study was to objectively investigate the effect of chemotherapy on mucociliary clearance and olfactory function and to evaluate whether this effect differs between different chemotherapy regimens and age groups. Patients and methods The study included consecutive patients admitted for the treatment of a variety of primary tumors (except head and neck and brain malignancies). Patients were evaluated for olfaction and mucociliary clearance before and immediately after completing the last session of chemotherapy cycles, according to the therapeutic protocol. For objective evaluation, the saccharine test was used for mucociliary clearance and the Sniffin' Sticks test for olfactory function. Of the 46 initial patients, 30 completed the study. Groups were formed according to the chemotherapy regimen (four groups: CA (doxorubicin + cyclophosphamide), Folfox (oxaliplatin +5-FU + folinic acid), DCF (docetaxel + cisplatin +5-FU), and GC (gemcitabine + cisplatin)) and according to age (two groups: < 55 years and > 55 years). Results In the overall analyses, significant deterioration was noted in both mucociliary clearance time and smell scores (olfactory threshold (OT), olfactory discrimination (OD), olfactory identification (OI), and the composite threshold-discrimination-identification (TDI) score). The changes in these scores showed no significant differences between chemotherapy groups. The decrease in OT and global TDI scores was more severe in the younger age group. Conclusions Chemotherapy impairs both the mucociliary clearance and olfactory function in cancer patients. This might reflect the collective negative effect of chemotherapy on olfactory function, not only through the neurocytotoxic effect but also the cytotoxic effect on the nasal mucosa. In addition, the reduction in olfactory threshold and total olfactory function scores was seen to be more profound in younger patients, which could have been due to higher initial scores.en_US
dc.identifier.doi10.1007/s00520-020-05639-y
dc.identifier.endpage1641en_US
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue3en_US
dc.identifier.pmid32749656en_US
dc.identifier.scopus2-s2.0-85089032609en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1635en_US
dc.identifier.urihttps://doi.org/10.1007/s00520-020-05639-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10971
dc.identifier.volume29en_US
dc.identifier.wosWOS:000555706300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSupportive Care In Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMucociliary Clearanceen_US
dc.subjectSniffin' Sticks Testen_US
dc.subjectOlfactionen_US
dc.subjectCanceren_US
dc.subjectChemotherapyen_US
dc.subjectToxicityen_US
dc.titleThe effect of chemotherapy on olfactory function and mucociliary clearanceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu