AGE AND SEX AFFECT SPATIAL AND EMOTIONAL BEHAVIORS IN RATS: THE ROLE OF REPEATED ELEVATED PLUS MAZE TEST

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dc.contributor.authorBelviranli, M.
dc.contributor.authorAtalik, K. E. N.
dc.contributor.authorOkudan, N.
dc.contributor.authorGokbel, H.
dc.date.accessioned2024-02-23T14:13:20Z
dc.date.available2024-02-23T14:13:20Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractThe main objective of the study was to investigate the effects of age and sex differences on locomotor activity, learning and memory in rats. Another objective was to investigate whether repeated elevated plus maze tests induce anxiety in rats. Eighty Wistar rats were divided into eight groups according to their sex, age and anxiety status. Locomotor activity was assessed in open field. Repeated anxiety tests were performed in elevated plus maze. Spatial learning and memory were evaluated with the Morris water maze. All behavioral tests were recorded online and analyzed offline with an analytical software. Exploratory behavior was lower in anxiety-induced rats. Male rats had lower anxiety levels, locomotor activity and exploratory behavior compared to females. During the training period of Morris water maze latency to find platform, total distance traveled and average swimming speed decreased in all groups with repeated tests and young rats generally were faster than aged rats. During the probe trial, although the number of platform crossings was not affected, time spent in the platform zone was higher in the young groups compared to the aged groups. In conclusion, age and sex affect locomotor activity, learning and memory in different aspects. (C) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipSelcuk University [SABE 11401037]en_US
dc.description.sponsorshipThe authors stated that there is no conflict of interest. The authors acknowledge Professor Said Bodur for statistical assistance. This work was supported by Scientific Research and Project Coordinator of the Selcuk University (Grant No. SABE 11401037).en_US
dc.identifier.doi10.1016/j.neuroscience.2012.09.036
dc.identifier.endpage9en_US
dc.identifier.issn0306-4522
dc.identifier.issn1873-7544
dc.identifier.pmid23018000en_US
dc.identifier.scopus2-s2.0-84867741460en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.neuroscience.2012.09.036
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12393
dc.identifier.volume227en_US
dc.identifier.wosWOS:000312113100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofNeuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehavioral Measurementen_US
dc.subjectAnxietyen_US
dc.subjectAgingen_US
dc.subjectSex Differenceen_US
dc.titleAGE AND SEX AFFECT SPATIAL AND EMOTIONAL BEHAVIORS IN RATS: THE ROLE OF REPEATED ELEVATED PLUS MAZE TESTen_US
dc.typeArticleen_US

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