Serum Vitamins A, D, and Zinc Levels in Children with Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children

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dc.contributor.authorYilmaz, Asli Imran
dc.contributor.authorUnal, Gokcen
dc.contributor.authorKeles, Sevgi
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorKilic, Ahmet Osman
dc.contributor.authorAkcan, Ozge Metin
dc.contributor.authorErdogan, Kubra Nur
dc.date.accessioned2024-02-23T14:16:59Z
dc.date.available2024-02-23T14:16:59Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective Vitamin D, due to its immunomodulating effect, zinc, and vitamin A, which affect cellular and humoral immunity, are thought to affect the clinical severity of coronavirus disease 2019 (COVID-19) infection. The present study evaluates the association between vitamin A, D, and zinc deficiencies and disease severity in pediatric patients with COVID-19 infections. Methods The levels of vitamin A, D, and zinc at the time of diagnosis of 123 pediatric patients who presented to our hospital and were diagnosed as having hospitalized, nonhospitalized COVID-19 infection group, and multisystem inflammatory syndrome in children (MIS-C) were evaluated. The correlations of the measured levels with the disease severity and the need for intensive care or hospitalization were analyzed. Results Among the 123 patients, 21.1% (n = 26), 42.2% (n = 52), and 36.7% (n = 45) had a diagnosis of MIS-C, belonged to the hospitalized COVID-19 infection group, or belonged to the nonhospitalized COVID-19 infection group, respectively. Zinc levels were significantly lower in the MIS-C group than in the nonhospitalized group (p < 0.05). Vitamin A levels were found to be significantly lower in the MIS-C group than in the nonhospitalized group (p < 0.01) and significantly lower in the hospitalized group when compared with the nonhospitalized group (p < 0.001). Deficiencies in vitamin A, vitamin D, and zinc levels were found to be most common in the MIS-C group (42.3%) and in hospitalized COVID-19 group (15.3%). In the nonhospitalized COVID-19 group, it was found to be the lowest at 6.6%. Conclusion Based on the results of the present study and a literature review, it can be said that vitamin A, D, and zinc deficiencies may associate with the severity of COVID-19, although more studies are required to clarify this subject further.en_US
dc.identifier.doi10.1055/s-0042-1756442
dc.identifier.endpage281en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85138615467en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1055/s-0042-1756442
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12882
dc.identifier.volume17en_US
dc.identifier.wosWOS:000854288600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal Of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCovid-19en_US
dc.subjectPandemicen_US
dc.subjectVitamin Den_US
dc.subjectVitamin Aen_US
dc.subjectZincen_US
dc.titleSerum Vitamins A, D, and Zinc Levels in Children with Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Childrenen_US
dc.typeArticleen_US

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