Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio

Basit Öğe Kaydı
dc.contributor.authorUslu, Ali Ugur
dc.contributor.authorKucuk, Adem
dc.contributor.authorSahin, Ali
dc.contributor.authorUgan, Yunus
dc.contributor.authorYilmaz, Ramazan
dc.contributor.authorGungor, Tayfun
dc.contributor.authorBagcaci, Sinan
dc.date.accessioned2024-02-23T14:24:00Z
dc.date.available2024-02-23T14:24:00Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractAimRheumatoid arthritis (RA) is an inflammatory autoimmune disease with unknown etiology and systemic involvement. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are two new inflammatory markers used in the assessment of systemic inflammation. The aim here is to study NLR and PLR in patients with RA to investigate their relation with Disease Activity Score of 28 joints (DAS-28). MethodsThe study included 104 patients with RA and a control group of 51 age- and gender-matched healthy subjects. We divided the patients into two groups according to the DAS-28 score. Group 1 included patients with a score of lower than 2.6 by the DAS-28 (patients in remission) and Group 2 included patients with a score of 2.6 and higher (patients with active disease). ResultsNLR was 2.120.83 in the patient group and 1.58 +/- 0.57 in the control group. PLR was 136.50 +/- 53.52 in the patient group and 114.84 +/- 29.41 in the control group. There was a statistically significant difference in NLR and PLR between the patient and control groups (P0.0001 and P=0.001, respectively). Patients in Group 1 had an NLR of 1.84 +/- 0.61 and a PLR of 119.25 +/- 41.77. Patients in Group 2 had an NLR of 2.29 +/- 0.90 and a PLR of 147.28 +/- 56.96. There was a statistically significant difference in NLR and PLR between the two groups (P=0.003 and P=0.005 respectively). A correlation was observed between NLR and PLR by DAS-28 (r=0.345, P0.0001 and r=0.352, P0.0001, respectively). ConclusionsThe present study showed us that NLR and PLR were two new inflammatory markers which could be used to assess disease activity in patients with RA.en_US
dc.identifier.doi10.1111/1756-185X.12582
dc.identifier.endpage735en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue7en_US
dc.identifier.pmid25900081en_US
dc.identifier.scopus2-s2.0-84940794996en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage731en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12582
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13761
dc.identifier.volume18en_US
dc.identifier.wosWOS:000360767400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDas-28en_US
dc.subjectNeutrophil-Lymphocyteen_US
dc.subjectPlatelet-Lymphocyteen_US
dc.subjectRatioen_US
dc.subjectRheumatoid Arthritisen_US
dc.titleTwo new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratioen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu