Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus

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dc.contributor.authorUslu, Ali Ugur
dc.contributor.authorKucuk, Adem
dc.contributor.authorIcli, Abdullah
dc.contributor.authorCure, Erkan
dc.contributor.authorSakiz, Davut
dc.contributor.authorArslan, Sevket
dc.contributor.authorBaykara, Rabia Aydogan
dc.date.accessioned2024-02-23T14:41:04Z
dc.date.available2024-02-23T14:41:04Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractObjective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria. Furthermore, we selected age-and body mass index (BMI)-matched 56 female healthy individuals. PAI was measured as a logarithmic value of triglyceride to high-density cholesterol ratio. We used carotid intima media thickness (cIMT) as an inflammatory marker because of its widespread use. The lipid and other biochemical parameters of patient and control groups were examined. Results: The PAI and cIMT values of SLE patients were 0.04 +/- 0.23 and 0.78 +/- 0.18 mm, respectively. Besides, for the control group, the PAI value was -0.09 +/- 0.20 and cIMT value was 0.50 +/- 0.15 mm (p=0.002, p<0.001; respectively). There was a strong correlation between cIMT and PAI (r=0.273, p=0.003). According to the multiple logistic regression analysis, we found that PAI value is an independent factor for cIMT in SLE patients (odds ratio: 2.6, 95 % confidence interval; 1.506-4.374; p=0.029). Conclusions: We determined that PAI can be used as an independent indicator for subclinical atherosclerosis in SLE patients.en_US
dc.identifier.doi10.5152/eurasianjmed.2017.17143
dc.identifier.endpage197en_US
dc.identifier.issn1308-8734
dc.identifier.issn1308-8742
dc.identifier.issue3en_US
dc.identifier.pmid29123443en_US
dc.identifier.scopus2-s2.0-85032356275en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.5152/eurasianjmed.2017.17143
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16697
dc.identifier.volume49en_US
dc.identifier.wosWOS:000413775600007en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofEurasian Journal Of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlasma Atherogenic Indexen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.subjectAtherosclerosisen_US
dc.titlePlasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosusen_US
dc.typeArticleen_US

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