Evaluation of arterial stiffness and serum endocan levels in patients with primary aldosteronism with new-onset hypertension and long-term hypertension

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dc.contributor.authorCan, M.
dc.contributor.authorKocabas, M.
dc.contributor.authorBurgucu, H. C.
dc.contributor.authorYarar, Z.
dc.contributor.authorKaradeniz, Y.
dc.contributor.authorKarakose, M.
dc.contributor.authorYerlikaya, F. H.
dc.date.accessioned2024-02-23T14:00:11Z
dc.date.available2024-02-23T14:00:11Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPurpose There is growing evidence that prolonged exposure to high serum aldosterone concentrations results in target organ damage to the heart, kidney, and arterial wall, and that primary aldosteronism (PA) is associated with increased cardiovascular risk. In this study, we aimed to evaluate cardiovascular disease (CVD) risk indicators such as arterial stiffness [with pulse wave velocity (PWV) measurement] in PA patients and endocan levels, which is a biomarker of endothelial dysfunction. Methods 28 patients with PA were included in our study. As the control group, 14 patients with essential hypertension (EHT) and 28 normotensive healthy volunteers were included. Height, weight, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum fasting glucose, insulin, hemoglobin A1c (HbA1c), C-reactive protein (CRP), lipids and endocan levels of all subjects in the PA, EHT and control groups were measured. PWV measurements were performed to assess arterial stiffness. Results In the PA group, PWV levels were similar to the EHT group, and endocan levels were lower than the EHT group. In the PA group, PWV levels were higher than the control group, and endocan levels were lower than the control group. When we compared the PA group with new-onset HT with the PA group with long-term HT, PWV levels were higher in the PA group with long-term HT. When we compared the long-term HT group with the EHT group, PWV levels were higher in the long-term HT PA group and endocan levels were higher in the EHT group. When we compared the PA group with long-term HT with the control group, PWV levels were higher in the PA group with long-term HT, and endocan levels were similar in both groups. Conclusions In our study, it was determined that arterial stiffness increased in PA cases with long-term HT compared to PA cases with new-onset HT, EHT cases and normotensive healthy cases. We found that endocan levels in PA patients were also lower than both EHT patients and healthy controls.en_US
dc.identifier.doi10.1007/s40618-022-01888-2
dc.identifier.endpage110en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue1en_US
dc.identifier.pmid35921036en_US
dc.identifier.scopus2-s2.0-85135350275en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://doi.org/10.1007/s40618-022-01888-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11489
dc.identifier.volume46en_US
dc.identifier.wosWOS:000835618800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArterial Stiffnessen_US
dc.subjectPrimary Aldosteronismen_US
dc.subjectEndocanen_US
dc.titleEvaluation of arterial stiffness and serum endocan levels in patients with primary aldosteronism with new-onset hypertension and long-term hypertensionen_US
dc.typeArticleen_US

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